Echo-Tracking Assessment of Carotid Artery Stiffness in Patients with Aortic Valve Stenosis
Article first published online: 26 MAY 2009
© 2009, the Authors Journal compilation © 2009, Wiley Periodicals, Inc.
Volume 26, Issue 7, pages 823–831, August 2009
How to Cite
Antonini-Canterin, F., Roşca, M., Beladan, C. C., Popescu, B. A., Piazza, R., Leiballi, E., Ginghină, C. and Nicolosi, G. L. (2009), Echo-Tracking Assessment of Carotid Artery Stiffness in Patients with Aortic Valve Stenosis. Echocardiography, 26: 823–831. doi: 10.1111/j.1540-8175.2008.00891.x
- Issue published online: 27 JUL 2009
- Article first published online: 26 MAY 2009
- carotid artery;
- arterial stiffness;
- duplex ultrasound;
- aortic stenosis;
Background: There is little information about mechanical properties of large arteries in patients (pts) with aortic stenosis (AS). Methods: Nineteen patients with AS (aortic valve area: 0.88 ± 0.29 cm2) and 24 control subjects without AS but with a similar distribution of risk factors were recruited. β index, pressure-strain elastic modulus (Ep), arterial compliance (AC), augmentation index (AIx), and local pulse-wave velocity (PWV) were obtained at the level of right common carotid artery (CCA) by a real time echo-tracking system. Time to dominant peak of carotid diameter change waveform, corrected for heart rate (tDPc), and maximum rate of rise of carotid diameter (dD/dt) were measured. Systemic arterial compliance (SAC) was also calculated. Parameters of AS severity (mean gradient, valve area, stroke work loss [SWL]) were determined. Results: tDPc was higher in patients with AS than in controls (7.9 ± 0.6 vs. 6.6 ± 0.7, P < 0.0001) while dD/dt was lower (5.3 ± 3.6 mm/s vs. 7.8 ± 2.8 mm/s, P = 0.01). AIx was significantly higher in AS group (32.5 ± 13.6% vs. 20.6 ± 12.2%, P = 0.005) and had a linear correlation both with tDPc (r = 0.63, P < 0.0001) and with dD/dt (r =−0.38, P = 0.01). There was a significant correlation between carotid AC and SAC (r = 0.49, P = 0.03), but only carotid AC was related to SWL (r = 0.51, P = 0.02), while SAC was not (P = 0.26).Conclusions: AIx was the only parameter of arterial rigidity found to be higher in patients with AS than in controls. Carotid AC showed a significant correlation with SAC and it seemed to be more closely related to AS severity than to SAC.