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Reference Values of Tissue Doppler Imaging and Pulsed Doppler Echocardiography for Analysis of Left Ventricular Diastolic Function in Healthy Adults

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Address for correspondence and reprint requests: Lilian C S Angelo, M.D., Ph.D., Rua Joaquim Lírio, 500/901, 29055-460, Vitória, Espírito Santo, Brazil. Fax: 55 11 3251 2701; E-mail: langel@terra.com.br

Abstract

To determine reference values for tissue Doppler imaging (TDI) and pulsed Doppler echocardiography for left ventricular diastolic function analysis in a healthy Brazilian adult population. Observations were based on a randomly selected healthy population from the city of Vitória, Espírito Santo, Brazil. Healthy volunteers (n = 275, 61.7% women) without prior histories of cardiovascular disease underwent transthoracic echocardiography. We analyzed 175 individuals by TDI and evaluated mitral annulus E′- and A′-waves from the septum (S) and lateral wall (L) to calculate E′/A′ ratios. Using pulsed Doppler echocardiography, we further analyzed the mitral E- and A-waves, E/A ratios, isovolumetric relaxation times (IRTs), and deceleration times (DTs) of 275 individuals. Pulsed Doppler mitral inflow mean values for men were as follows: E-wave: 71 ± 16 cm/sec, A-wave: 68 ± 15 cm/sec, IRT: 74.8 ± 9.2 ms, DT: 206 ± 32.3 ms, E/A ratio: 1.1 ± 0.3. Pulsed Doppler mitral inflow mean values for women were as follows: E-wave: 76 ± 17, A-wave: 69 ± 14 cm/sec, IRT: 71.2 ± 10.5 ms, DT: 197 ± 33.3 ms, E/A ratio: 1.1 ± 0.3. IRT and DT values were higher in men than in women (P = 0.04 and P = 0.007, respectively). TDI values in men were as follows: E′S: 11± 3 cm/sec, A′S: 13 ± 2 cm/sec, E′S/A′S: 0.89 ± 0.2, E′L: 14 ± 3 cm/sec, A′L: 14 ± 2 cm/sec, E′L/A′L: 1.1± 0.4. E-wave/ E′S ratio: 6.9 ± 2.2; E-wave / E′L ratio: 4.9 ± 1.7. In this study, we determined pulsed Doppler and TDI derived parameters for left ventricular diastolic function in a large sample of healthy Brazilian adults. (Echocardiography 2010;27:777-782)

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