Hypercholesterolemia Association with Aortic Stenosis of Various Etiologies
Version of Record online: 24 FEB 2009
© 2009 Wiley Periodicals, Inc.
Journal of Cardiac Surgery
Volume 24, Issue 2, pages 146–150, March 2009
How to Cite
Rabuş, M. B., Kayalar, N., Sareyyüpoğlu, B., Erkin, A., Kırali, K. and Yakut, C. (2009), Hypercholesterolemia Association with Aortic Stenosis of Various Etiologies. Journal of Cardiac Surgery, 24: 146–150. doi: 10.1111/j.1540-8191.2009.00814.x
- Issue online: 24 FEB 2009
- Version of Record online: 24 FEB 2009
Abstract Background: Hypercholesterolemia has been found to be associated with aortic valve stenosis and to resemble the inflammatory process of atherosclerosis in many studies. The aim of this study was to investigate the role of hypercholesterolemia in development of aortic valve calcification in different etiologies. Methods: The study included 988 patients with rheumatic, congenital, or degenerative aortic stenosis, who underwent aortic valve replacement at Koşuyolu Heart and Research Hospital between 1985 and 2005. Effects of hypercholesterolemia and high low-density lipoprotein level on calcific aortic stenosis or massive aortic valve calcification were analyzed for each etiologic group. Results: Both univariate and multivariate analyses revealed that the high serum cholesterol level (>200 mg/dL) was related to massive aortic valve calcification in all patients (p = 0.003). Hypercholesterolemia was linked to calcific aortic stenosis and massive calcification in patients with degenerative etiology (p = 0.02 and p = 0.01, respectively) and it was related to massive calcification in patients with congenital bicuspid aorta (p = 0.02). Other independent risk factors for calcific aortic stenosis and massive calcification in the degenerative group were high low-density lipoprotein level (>130 mg/dL; p = 0.03 and p = 0.05, respectively) and high serum C-reactive protein level (p = 0.04 and p = 0.05, respectively). Conclusions: Hypercholesterolemia is related to increased risk of aortic valve calcification in patients with degenerative and congenital etiology. Preventive treatment of hypercholesterolemia could play an important role to decrease or inhibit development of aortic valve calcification.