Effects of Psoralen-UV-A-Turban in Alopecia Areata
Article first published online: 6 FEB 2007
SKINmed: Dermatology for the Clinician
Volume 5, Issue 2, pages 64–68, March/April 2006
How to Cite
Grazyna, B.-D., Anna, W.-K., Matgorzata, D.-B. and Magdalena, P.-B. (2006), Effects of Psoralen-UV-A-Turban in Alopecia Areata. SKINmed: Dermatology for the Clinician, 5: 64–68. doi: 10.1111/j.1540-9740.2006.04240.x
- Issue published online: 6 FEB 2007
- Article first published online: 6 FEB 2007
Background. Psoralen-UV-A (PUVA)-turban is a modification of PUVA-bath therapy used in alopecia areata.
Objective. The aim of this study was to assess the efficacy of PUVA-turban in different forms of alopecia areata. Twenty patients completed the study: nine with alopecia areata vulgaris and 11 with alopecia areata totalis or universalis.
Methods. 8-methoxypsoralen in a dilution of 0.0001% (1 mg/L) was administered to the scalp for 20 minutes using a cotton towel as a turban. The application was followed by UV-A radiation. Treatments were performed two or three times weekly. The cumulative doses ranged from 48.2–253.4 J/cm2, and single fractions ranged from 0.3–6.5 J/cm2.
Results. Hair regrowth was observed in 15 patients (total regrowth in six patients and partial regrowth in nine patients). Five patients did not respond to the therapy.
Conclusions. PUVA-turban was significantly more effective in alopecia areata vulgaris than in alopecia areata totalis or universalis and proved to be a safe, well tolerated method without the systemic side effects of PUVA.