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Multicentric Reticulohistiocytosis: A Proliferation of Macrophages With Tropism for Skin and Joints, Part I

Authors

  • Flávio Barbosa Luz MD, PhD,

    1. From the Sector of Dermatology, University Hospital HUCFF/UFRJ and School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;1 the Sector of Dermatology, University Hospital HUAP/UFF and School of Medicine, Universidade Federal Fluminense, Niterói, Brazil;2 and the Sector of Dermatology, University Hospital HUPE/UERJ and School of Medicine, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil3
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  • 1 Neide Kalil Gaspar MD, PhD,

    1. From the Sector of Dermatology, University Hospital HUCFF/UFRJ and School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;1 the Sector of Dermatology, University Hospital HUAP/UFF and School of Medicine, Universidade Federal Fluminense, Niterói, Brazil;2 and the Sector of Dermatology, University Hospital HUPE/UERJ and School of Medicine, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil3
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  • 2 Antonio Pedro Gaspar MD, PhD,

    1. From the Sector of Dermatology, University Hospital HUCFF/UFRJ and School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;1 the Sector of Dermatology, University Hospital HUAP/UFF and School of Medicine, Universidade Federal Fluminense, Niterói, Brazil;2 and the Sector of Dermatology, University Hospital HUPE/UERJ and School of Medicine, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil3
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  • 2 Sueli Carneiro MD, PhD,

    1. From the Sector of Dermatology, University Hospital HUCFF/UFRJ and School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;1 the Sector of Dermatology, University Hospital HUAP/UFF and School of Medicine, Universidade Federal Fluminense, Niterói, Brazil;2 and the Sector of Dermatology, University Hospital HUPE/UERJ and School of Medicine, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil3
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  • and 1,3 Marcia Ramos-e-Silva MD, PhD 1

    1. From the Sector of Dermatology, University Hospital HUCFF/UFRJ and School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;1 the Sector of Dermatology, University Hospital HUAP/UFF and School of Medicine, Universidade Federal Fluminense, Niterói, Brazil;2 and the Sector of Dermatology, University Hospital HUPE/UERJ and School of Medicine, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil3
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Flávio Barbosa Luz, MD, PhD, Rua Desembargador Izidro, 28 / 1001, ZIP code 20.521–160 Rio de Janeiro, Brazil
E-mail: luzfb@globo.com

Abstract

The authors present part I of a review of multicentric reticulohistiocytosis, a rare systemic proliferative disease of histiocytes of unknown cause. It is clinically characterized by cutaneous and mucosal nodules and by osteoarticular lesions. The disease occurs in outbreaks that progress in severity, with spontaneous regression, but usually leaving incapacitating arthritis and disfiguring facial lesions. The authors discuss the historical, epidemiologic, and clinical aspects of this disease.

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