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Keywords:

  • Bonferroni–Holm;
  • Bootstrap;
  • Discreteness;
  • Exact tests;
  • Multiple comparisons;
  • Postmarket surveillance;
  • Predictive model

Summary Methods for performing multiple tests of paired proportions are described. A broadly applicable method using McNemar's exact test and the exact distributions of all test statistics is developed; the method controls the familywise error rate in the strong sense under minimal assumptions. A closed form (not simulation-based) algorithm for carrying out the method is provided. A bootstrap alternative is developed to account for correlation structures. Operating characteristics of these and other methods are evaluated via a simulation study. Applications to multiple comparisons of predictive models for disease classification and to postmarket surveillance of adverse events are given.