Multiple McNemar Tests
Article first published online: 25 MAR 2010
© 2010, The International Biometric Society
Volume 66, Issue 4, pages 1185–1191, December 2010
How to Cite
Westfall, P. H., Troendle, J. F. and Pennello, G. (2010), Multiple McNemar Tests. Biometrics, 66: 1185–1191. doi: 10.1111/j.1541-0420.2010.01408.x
- Issue published online: 25 MAR 2010
- Article first published online: 25 MAR 2010
- Received August 2009. Revised January 2010. Accepted January 2010.
- Exact tests;
- Multiple comparisons;
- Postmarket surveillance;
- Predictive model
Summary Methods for performing multiple tests of paired proportions are described. A broadly applicable method using McNemar's exact test and the exact distributions of all test statistics is developed; the method controls the familywise error rate in the strong sense under minimal assumptions. A closed form (not simulation-based) algorithm for carrying out the method is provided. A bootstrap alternative is developed to account for correlation structures. Operating characteristics of these and other methods are evaluated via a simulation study. Applications to multiple comparisons of predictive models for disease classification and to postmarket surveillance of adverse events are given.