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Keywords:

  • Conditional likelihood;
  • Generalized linear mixed models;
  • Misspecified random effect distributions;
  • Power

SummaryLitière, Alonso, and Molenberghs (2007, Biometrics, 63, 1038–1044) presented the results of simulation studies that they claimed showed that misspecification of the shape of the random effects distribution can produce marked increases in Type II error (decreases in power) of tests based on fits of generalized linear mixed models. However, the article contains a logical fallacy that invalidates this claim. We present logically correct simulation studies that demonstrate little increase in Type II error, consistent with the earlier work that shows little effect due to misspecification.