The Use of Two-Way Linear Mixed Models in Multitreatment Meta-Analysis
Article first published online: 27 JUL 2012
© 2012, The International Biometric Society
Volume 68, Issue 4, pages 1269–1277, December 2012
How to Cite
Piepho, H. P., Williams, E. R. and Madden, L. V. (2012), The Use of Two-Way Linear Mixed Models in Multitreatment Meta-Analysis. Biometrics, 68: 1269–1277. doi: 10.1111/j.1541-0420.2012.01786.x
- Issue published online: 21 DEC 2012
- Article first published online: 27 JUL 2012
- Received October 2011. Revised April 2012. Accepted April 2012.
- Mixed treatment comparisons;
- Multiple-treatments meta-analysis;
- Network meta-analysis
Summary Meta-analysis summarizes the results of a series of trials. When more than two treatments are included in the trials and when the set of treatments tested differs between trials, the combination of results across trials requires some care. Several methods have been proposed for this purpose, which feature under different labels, such as network meta-analysis or mixed treatment comparisons. Two types of linear mixed model can be used for meta-analysis. The one expresses the expected outcome of treatments as a contrast to a baseline treatment. The other uses a classical two-way linear predictor with main effects for treatment and trial. In this article, we compare both types of model and explore under which conditions they give equivalent results. We illustrate practical advantages of the two-way model using two published datasets. In particular, it is shown that between-trial heterogeneity as well as inconsistency between different types of trial is straightforward to account for.