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Recurrence Risk of Hyperemesis Gravidarum


  • Marlena S. Fejzo PhD,

  • Kimber W. MacGibbon RN,

  • Roberto Romero MD,

  • T. Murphy Goodwin MD,

  • Patrick M. Mullin MD

Address correspondence to Marlena S. Fejzo, PhD, 5535 MRL, University of California at Los Angeles, 675 Charles E. Young Drive South, Los Angeles, CA 90095. E-mail:


Introduction: The purpose of this study is to describe the recurrence risk for hyperemesis gravidarum (HG).

Methods: Women who registered on a Web site sponsored by the Hyperemesis Education and Research Foundation as having had one HG-complicated pregnancy were contacted to follow-up on a subsequent pregnancy. Participants completed an online survey.

Results: One hundred women responded. Fifty-seven had become pregnant again, 2 were trying to conceive, 37 were not willing to get pregnant again because of HG, and 4 did not have a second pregnancy for other reasons. Among the 57 women who responded that they had become pregnant again, 81% reported having severe nausea and vomiting in their second pregnancy. Among the women reporting recurrent HG, 98% reported losing weight and taking prescribed medication for HG, 83% reported treatment with intravenous fluids, 20% reported treatment with total parenteral nutrition or nasogastric tube feeding, and 48% reported hospitalization for HG.

Discussion: This study demonstrates both a high recurrence rate of HG and a large percentage of women who change reproductive plans because of their experiences with HG.