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The article “Magnesium Sulfate: Past, Present, and Future,” that was published in the November/December 2011 issue of the Journal (2011;56:566–574) contained an error in Table 2. Footnote ‘f’ of Table 2 (page 569) should read, “Can repeat full protocol (loading dose and infusion) after 12h if birth again seems imminent, but the infusion can be restarted after 6 hours.”

The correct version of the table is as follows:

Table 2. Recommended Magnesium Sulfate Dosing Guidelines10,18,52
Clinical IndicationsLoading Dose: IM ProtocolaLoading Dose: IV ProtocolMaintenance: Periodic IM InjectionsMaintenance: Continuous IV Infusion
  1. Abbreviations: IM, intramuscular; IV, intravenous; N/A, not applicable.

  2. aInitial dose is given via slow IV push.

  3. bA second bolus of 2 g can be given IV over 3-5 min for acute seizure management.

  4. cAll IV doses should be diluted to 20% solution.

  5. dIM doses can be given undiluted (50% solution).

  6. eRecommended only if gestational age is 24 0/7 to 31 6/7 wk with imminent risk of birth within 24 h.

  7. fCan repeat full protocol (loading dose and infusion) after 12h if birth again seems imminent, but the infusion can be restarted after 6 hours.

Seizure prophylaxis: eclampsiab or severe preeclampsia4 g (20%)c IV at 1 g/min, then follow immediately with IM dosing4-6 g (20%) in 100 mL over 15-20 min10 g (50%)d 5 g deep IM each buttock. Repeat every 4 h2 g/h (20%) continued until 24 h after birth
Cerebral palsy prophylaxis: preterm laboreN/A6 g (20%) in 100 mL over 20-30 minN/A2 g/h (20%) for up to 12 hf