Presented at the XXII Congress of the European Society of Cardiology, September 2001, Stockholm, Sweden.
Vectorcardiography Risk Stratifies Emergency Department Chest Pain Patients with Left Ventricular Hypertrophy on the Initial 12-Lead ECG
Article first published online: 13 APR 2004
Annals of Noninvasive Electrocardiology
Volume 9, Issue 2, pages 149–155, April 2004
How to Cite
Fesmire, F. M. and Eriksson, S. V. (2004), Vectorcardiography Risk Stratifies Emergency Department Chest Pain Patients with Left Ventricular Hypertrophy on the Initial 12-Lead ECG. Annals of Noninvasive Electrocardiology, 9: 149–155. doi: 10.1111/j.1542-474X.2004.92536.x
This study was supported from unrestricted research grants from Hewlett-Packard (currently Phillips Medical Technologies), Cor Therapeutics (currently Millenium Pharmaceuticals), DuPont Radio Pharmaceuticals (currently Bristol-Myers Squibb Medical Imaging), and EmCare, Inc.
- Issue published online: 13 APR 2004
- Article first published online: 13 APR 2004
- acute myocardial infarction;
- acute coronary syndromes;
- ST-vector magnitude;
- QRS-vector difference;
- ST-segment monitoring
Background: Vectorcardiographic (VCG) measurements of ST-vector magnitude (VM) and QRS-vector difference (VD) have been demonstrated to be independent predictors of adverse outcome (AO) and acute myocardial infarction (AMI) in emergency department (ED) chest pain patients with absence of bundle branch block or left ventricular hypertrophy (LVH) on the initial 12-lead electrocardiogram (ECG). The prognostic value of ST-VM and QRS-VD in ED chest pain patients with LVH on the initial 12-lead ECG has not been previously investigated.
Methods: A prospective observational study was performed in 196 consecutive ED chest pain patients with suspected AMI and presence of voltage criteria for LVH on initial ECG who underwent continuous VCG monitoring during the initial evaluation. The optimal baseline ST-VM value and 2-hour QRS-VD value were defined as the most accurate value on the receiver operator characteristic curve (value with lowest false-negative and false-positive rate). Thirty-day AO was defined as AMI, percutaneous coronary intervention, coronary artery bypass grafting (CABG), or cardiac death occurring within 30 days of initial ED visit.
Results: Fourteen patients (7.1%) were diagnosed as 24-hour AMI and 28 patients (14.3%) experienced 30-day AO. The optimal cut-off value for predicting 30-day AO was >124 μV for ST-VM and >21.7 μV for QRS-VD. Patients with either a positive ST-VM or a positive QRS-VD had 8.8 times increased odds of AMI (95% confidence interval, CI, 1.9–40.3; P = 0.003); 4.3 times increased odds of 30-day PTCA/CABG (95% CI 1.3–13.8; P = 0.019); and 3.8 times increased odds of 30-day AO (95% CI 1.6–9.3; P = 0.003).
Conclusions: Baseline ST-VM and 2-hour QRS-VD risk stratifies ED chest pain patients with LVH voltage criteria on the initial 12-lead ECG.