• genetics;
  • obesity;
  • diabetes;
  • nutrition

Purpose: To present evidence of genetic and environmental interactions as they relate to nutrition, diabetes, and obesity.

Methods: A review of seminal literature related to genetics, obesity, and diabetes.

Findings: Multifactorial interactions are important in the development of nutrition-related disorders, but the challenge remains to explain how these interactions are expressed. Treating subpopulations of people might be important and useful to some extent at present, but in the future treating people of given genetic predispositions and other personal and environmental factors will have greater effects on quality-of-life indicators and life expectancies.

Conclusions: Individualization coupled with multifactorial interactions will lead to new and more effective preventive and treatment modalities of nutrition-related disorders. With obesity and diabetes, genomics will bridge the traditional use of diet, exercise, and weight reduction with other environmental factors, ultimately leading to healthier lives.