An Intervention Study to Prevent Relapse in Patients With Schizophrenia

Authors

  • B. Van Meijel,

    1. B. van Meijel, RN, PhD, Rho Chi, Researcher, Department of Nursing Science, University Medical Center Utrecht and Associate professor, INHOLLAND University, Amsterdam; C. Kruitwagen, MSc, Statistician, Center for Bio-Statistics, Utrecht University; M. van der Gaag, PhD, Researcher, Clinical Psychologist, Parnassia Psychiatric Institute, The Hague; R.S. Kahn, PhD, Professor, Department of Neuroscience, University Medical Center Utrecht; M.H.F. Grypdonck, RN, PhD, Rho Chi, Professor, Department of Nursing Science, University Medical Center Utrecht; all in The Netherlands. This study was financially supported by grants from Vereniging voor Academische Ziekenhuizen (Association of University Hospitals), College voor Zorgverzekeringen (Board of Health Insurances) and Eli Lilly The Netherlands. Correspondence to Dr. van Meijel, Department of Nursing Science, University Medical Center Utrecht, PO-Box 85060, 3508 AB Utrecht, The Netherlands. E-mail: B.K.G.vanMeijel@umcutrecht.nl
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  • C. Kruitwagen,

    1. B. van Meijel, RN, PhD, Rho Chi, Researcher, Department of Nursing Science, University Medical Center Utrecht and Associate professor, INHOLLAND University, Amsterdam; C. Kruitwagen, MSc, Statistician, Center for Bio-Statistics, Utrecht University; M. van der Gaag, PhD, Researcher, Clinical Psychologist, Parnassia Psychiatric Institute, The Hague; R.S. Kahn, PhD, Professor, Department of Neuroscience, University Medical Center Utrecht; M.H.F. Grypdonck, RN, PhD, Rho Chi, Professor, Department of Nursing Science, University Medical Center Utrecht; all in The Netherlands. This study was financially supported by grants from Vereniging voor Academische Ziekenhuizen (Association of University Hospitals), College voor Zorgverzekeringen (Board of Health Insurances) and Eli Lilly The Netherlands. Correspondence to Dr. van Meijel, Department of Nursing Science, University Medical Center Utrecht, PO-Box 85060, 3508 AB Utrecht, The Netherlands. E-mail: B.K.G.vanMeijel@umcutrecht.nl
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  • M. Van Der Gaag,

    1. B. van Meijel, RN, PhD, Rho Chi, Researcher, Department of Nursing Science, University Medical Center Utrecht and Associate professor, INHOLLAND University, Amsterdam; C. Kruitwagen, MSc, Statistician, Center for Bio-Statistics, Utrecht University; M. van der Gaag, PhD, Researcher, Clinical Psychologist, Parnassia Psychiatric Institute, The Hague; R.S. Kahn, PhD, Professor, Department of Neuroscience, University Medical Center Utrecht; M.H.F. Grypdonck, RN, PhD, Rho Chi, Professor, Department of Nursing Science, University Medical Center Utrecht; all in The Netherlands. This study was financially supported by grants from Vereniging voor Academische Ziekenhuizen (Association of University Hospitals), College voor Zorgverzekeringen (Board of Health Insurances) and Eli Lilly The Netherlands. Correspondence to Dr. van Meijel, Department of Nursing Science, University Medical Center Utrecht, PO-Box 85060, 3508 AB Utrecht, The Netherlands. E-mail: B.K.G.vanMeijel@umcutrecht.nl
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  • R.S. Kahn,

    1. B. van Meijel, RN, PhD, Rho Chi, Researcher, Department of Nursing Science, University Medical Center Utrecht and Associate professor, INHOLLAND University, Amsterdam; C. Kruitwagen, MSc, Statistician, Center for Bio-Statistics, Utrecht University; M. van der Gaag, PhD, Researcher, Clinical Psychologist, Parnassia Psychiatric Institute, The Hague; R.S. Kahn, PhD, Professor, Department of Neuroscience, University Medical Center Utrecht; M.H.F. Grypdonck, RN, PhD, Rho Chi, Professor, Department of Nursing Science, University Medical Center Utrecht; all in The Netherlands. This study was financially supported by grants from Vereniging voor Academische Ziekenhuizen (Association of University Hospitals), College voor Zorgverzekeringen (Board of Health Insurances) and Eli Lilly The Netherlands. Correspondence to Dr. van Meijel, Department of Nursing Science, University Medical Center Utrecht, PO-Box 85060, 3508 AB Utrecht, The Netherlands. E-mail: B.K.G.vanMeijel@umcutrecht.nl
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  • M.H.F. Grypdonck

    1. B. van Meijel, RN, PhD, Rho Chi, Researcher, Department of Nursing Science, University Medical Center Utrecht and Associate professor, INHOLLAND University, Amsterdam; C. Kruitwagen, MSc, Statistician, Center for Bio-Statistics, Utrecht University; M. van der Gaag, PhD, Researcher, Clinical Psychologist, Parnassia Psychiatric Institute, The Hague; R.S. Kahn, PhD, Professor, Department of Neuroscience, University Medical Center Utrecht; M.H.F. Grypdonck, RN, PhD, Rho Chi, Professor, Department of Nursing Science, University Medical Center Utrecht; all in The Netherlands. This study was financially supported by grants from Vereniging voor Academische Ziekenhuizen (Association of University Hospitals), College voor Zorgverzekeringen (Board of Health Insurances) and Eli Lilly The Netherlands. Correspondence to Dr. van Meijel, Department of Nursing Science, University Medical Center Utrecht, PO-Box 85060, 3508 AB Utrecht, The Netherlands. E-mail: B.K.G.vanMeijel@umcutrecht.nl
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Abstract

Purpose: To determine whether the use of relapse prevention plans (RPPs) in nursing practice is an effective intervention in reducing relapse rates among patients with schizophrenia.

Design and Methods: Experimental design. Patients with schizophrenia (or a related psychotic disorder) and nurses from three mental health organizations were randomly assigned to either an experimental (RPP) or control condition (care as usual). The primary outcome measure was the psychotic relapses in the research groups.

Results: The relapse rates in the experimental and control groups after 1-year follow-up were 12.5% and 26.2%, respectively (p=.12, ns). The relative risk of a relapse in the experimental versus the control group was 0.48(ns).

Conclusions: In this study no statistically significant effects of the intervention were found. Effectiveness research in this area should be continued with larger sample sizes and longer follow-up periods.

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