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Factors That Influence Characteristics of Genetic Biobanks

Authors

  • Jennifer E. Sanner,

    1. Jennifer E. Sanner, RN, MSN, Zeta Pi, Research Nurse Specialist, University of Texas Health Science Center at Houston, School of Nursing; Lorraine Frazier, RN, MS, DSN, NP, Zeta Pi, Associate Professor, University of Texas Health Science Center at Houston, School of Nursing and Senior Clinical Nurse Scientist, Texas Heart Institute and St. Luke's Episcopal Hospital; both in Houston, TX. This work was supported by Grant K23 NR08427-02 from the National Institute for Nursing Research, National Institutes of Health and TexGen Research. Correspondence to Dr. Frazier, 6901 Bertner, Suite 577, Houston, TX 77030. E-mail: lorraine.frazier@uth.tmc.edu
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  • Lorraine Frazier

    1. Jennifer E. Sanner, RN, MSN, Zeta Pi, Research Nurse Specialist, University of Texas Health Science Center at Houston, School of Nursing; Lorraine Frazier, RN, MS, DSN, NP, Zeta Pi, Associate Professor, University of Texas Health Science Center at Houston, School of Nursing and Senior Clinical Nurse Scientist, Texas Heart Institute and St. Luke's Episcopal Hospital; both in Houston, TX. This work was supported by Grant K23 NR08427-02 from the National Institute for Nursing Research, National Institutes of Health and TexGen Research. Correspondence to Dr. Frazier, 6901 Bertner, Suite 577, Houston, TX 77030. E-mail: lorraine.frazier@uth.tmc.edu
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Abstract

Purpose: To identify demographic differences between patients who choose participation and patients who choose nonparticipation in genetic biobanks, and to explore reasons for nonparticipation.

Design: Prospective study of hospitalized cardiovascular patients approached to participate in a genetic biobank, 300 nonparticipants and 299 participants, in the southwestern US.

Methods: Reasons for nonparticipation were explored. Logistic regression was performed to determine if gender, race or ethnicity, or age predicted nonparticipation.

Findings: Race or ethnicity and age were significantly different between participants and nonparticipants, but gender was not. Blood-sample collection was the main reason for declining participation.

Conclusions: Minority and older adults were less likely to participate. Understanding reasons for nonparticipation in this group might aid in the development of methods used to obtain a diverse population in biobanks.

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