Present address: Molecular Immunology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
The Role of miRNA in Stem Cell Pluripotency and Commitment to the Vascular Endothelial Lineage
Version of Record online: 27 MAR 2012
© 2012 John Wiley & Sons Ltd
Volume 19, Issue 3, pages 196–207, April 2012
How to Cite
WHITE, K., KANE, N. M., MILLIGAN, G. and BAKER, A. H. (2012), The Role of miRNA in Stem Cell Pluripotency and Commitment to the Vascular Endothelial Lineage. Microcirculation, 19: 196–207. doi: 10.1111/j.1549-8719.2012.00161.x
- Issue online: 27 MAR 2012
- Version of Record online: 27 MAR 2012
- Accepted manuscript online: 13 JAN 2012 02:31PM EST
- Received 2 November 2011; accepted 8 January 2012.
- pluripotent stem cells;
- endothelial cell differentiation;
Please cite this paper as: White K, Kane NM, Milligan G, Baker AH. The role of miRNA in stem cell pluripotency and commitment to the vascular endothelial lineage. Microcirculation19: 196–207, 2012.
Vascular endothelial cells derived from human pluripotent stem cells have substantial potential for the development of novel vascular therapeutics and cell-based therapies for the repair of ischemic damage. To gain maximum benefit from this source of cells, a complete understanding of the changes in gene expression and how they are regulated is required. miRNAs have been demonstrated to play a critical role in controlling stem cell pluripotency and differentiation and are important for mature endothelial cell function. Specific miRNAs that determine stem cell fate have been identified for a number of different cell lineages; however, in the case of differentiation and specification of vascular endothelial cells, this is yet to be fully elucidated.