The fatigue of mechanical strain induced by electric fields was investigated for antiferroelectric Pb0.97La0.02(Zr0.77Sn0.14Ti0.09)O3 ceramics. The material shows a high resistance to fatigue owing to bipolar electric cycling up to 108 cycles. The strain hysteresis loop is still fairly symmetric, whereas the maximum field-induced strain decreases by only 30% of its initial value. The fatigued samples show a damaged microstructure with dendritic macrocracks and microcrack clouds. The fatigue is attributed to a combination of electrochemical and mechanical mechanisms.