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Structural Characterization and Protein Adsorption Property of Hydroxyapatite Particles Modified With Zinc Ions


  • D. Johnson—contributing editor

  • This study was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (No. 16360330, Z1416005).

†Author to whom correspondence should be addressed. e-mail:


Zinc-containing hydroxyapatite particles (Zn/HAp) were prepared by an ion exchange reaction process involving hydroxyapatite (HAp) particles with aqueous solutions containing various amounts of zinc nitrate. The Zn2+ ion was partially substituted for the Ca2+ ion position in the HAp lattice, and hence, the obtained samples had changed little in crystallinity, particle size, and specific surface area. Adsorption of bovine serum albumin (BSA) and β2-microglobulin (β2-MG) in solutions containing both BSA and β2-MG was examined. As the Zn2+ ion content in the apatites increased, the adsorbed amount of BSA was almost constant, whereas that of β2-MG increased.