The stack-and-draw technique has been used to fabricate photonic crystal fibers (PCFs) from four different types of soft glass, namely, borosilicate, alkaline, lead, and tungsten–tellurite. The thermophysical properties of the components must be matched in order to produce PCFs from a combination of glass types. Lead/alkaline PCFs could be fabricated without crystallization or fragility problems. Using borosilicate glass alone, PCFs with up to five hollow periodic structures could be formed. With tungsten–tellurite glass, a PCF with one hollow periodic structure and a core doped with Er3+ ions have been produced. The properties of this fiber confirm its potential application in optical amplification or in other active devices.