High Surface Area Nanomacroporous Bioactive Glass Scaffold for Hard Tissue Engineering

Authors

  • Shaojie Wang,

    1. Department of Materials Science and Engineering, Lehigh University, Bethlehem, Pennsylvania 18015
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  • Himanshu Jain

    Corresponding author
    1. Department of Materials Science and Engineering, Lehigh University, Bethlehem, Pennsylvania 18015
      †Author to whom correspondence should be addressed. e-mail: h.jain@lehigh.edu
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  • G. Fischman—contributing editor

  • This work was supported by the National Science Foundation (DMR-0602975 and DMR-0844014).

†Author to whom correspondence should be addressed. e-mail: h.jain@lehigh.edu

Abstract

Formation of sufficiently large three-dimensional (3D) nanomacroporosity in bone scaffolds remains a challenge in spite of several methods reported in literature. It is required for tissue ingrowth and for the concurrent degradation of implanted structure. We report a new technique for fabricating superior high surface area, nanomacroporous bioactive glass scaffold, which combines the sol–gel process and polymer sponge replication method. The formation of 3D structure is demonstrated in 70 mol% SiO2–30 mol% CaO glass composition as an example, which is uniform across the sample. It consists of open, interconnected macropores with size from 300 to 600 μm, as desired for tissue ingrowth. At the same time, coexisting nanopores provide high-specific surface area (∼184 m2/g), which is needed for enhancing the structure's degradation rate. These bioscaffolds hold promise for applications in hard tissue engineering.

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