Zn-Releasing FHA Coating and Its Enhanced Osseointegration Ability

Authors

  • Shundong Miao,

    1. State Key Laboratory of Silicon Materials, Department of Materials Science & Engineering, Zhejiang University, Hangzhou 310027, China
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    • H.-E. Kim—contributing editor

  • Nong Lin,

    1. Department of Orthopaedic Surgery, the Second Affiliated Hospital, Medical College of Zhejiang University,Hangzhou 310009, China
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    • H.-E. Kim—contributing editor

  • Kui Cheng,

    1. State Key Laboratory of Silicon Materials, Department of Materials Science & Engineering, Zhejiang University, Hangzhou 310027, China
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  • Disheng Yang,

    1. Department of Orthopaedic Surgery, the Second Affiliated Hospital, Medical College of Zhejiang University,Hangzhou 310009, China
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  • Xin Huang,

    1. Department of Orthopaedic Surgery, the Second Affiliated Hospital, Medical College of Zhejiang University,Hangzhou 310009, China
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  • Gaorong Han,

    1. State Key Laboratory of Silicon Materials, Department of Materials Science & Engineering, Zhejiang University, Hangzhou 310027, China
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  • Wenjian Weng,

    Corresponding author
    1. State Key Laboratory of Silicon Materials, Department of Materials Science & Engineering, Zhejiang University, Hangzhou 310027, China
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  • Zhaoming Ye

    1. Department of Orthopaedic Surgery, the Second Affiliated Hospital, Medical College of Zhejiang University,Hangzhou 310009, China
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  • This work was financially supported by the National Natural Science Foundation (50872122), Research Fund of the Doctoral Program of Higher Education of China (200703351015), and the research fund of Shenzhen Key Laboratory of Functional Polymers.

  • 1Contributed equally.

†Author to whom correspondence should be addressed. e-mail: wengwj@zju.edu.cn

Abstract

In this study, we present a novel coating with Zn-releasing ability that promotes osseointegration of Ti6Al4V implants. The coatings were prepared by a sol–gel technique, and nanosized Zn-containing β-tricalcium phosphate particles were added to the Ca(NO3)2–P2O5–HPF6 sol system to incorporate Zn ions into fluoridated hydroxyapatite (FHA) coatings. The derived Zn-releasing fluoridated hydroxyapatite (ZTFHA) coatings demonstrated a slow and sustained Zn release behavior. The ZTFHA coatings were able to support cell growth of osteoblast-like cell cultures and promoted an obvious increase in cell viability compared with FHA coating alone. The histological analysis of the ZTFHA coating showed direct bonding to bony tissue and significantly higher bone contact than with FHA coating alone. The ZTFHA coating with its slow and sustained Zn release shows promise as a medium for significantly enhancing osseointegration and allowing cementless stable fixation of orthopedic implants.

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