S. Bose—contributing editor
Fabrication and Characterization of Hydroxyapatite/Wollastonite Composite Bioceramics with Controllable Properties for Hard Tissue Repair
Article first published online: 3 SEP 2010
© 2010 The American Ceramic Society
Journal of the American Ceramic Society
Volume 94, Issue 1, pages 99–105, January 2011
How to Cite
Lin, K., Zhang, M., Zhai, W., Qu, H. and Chang, J. (2011), Fabrication and Characterization of Hydroxyapatite/Wollastonite Composite Bioceramics with Controllable Properties for Hard Tissue Repair. Journal of the American Ceramic Society, 94: 99–105. doi: 10.1111/j.1551-2916.2010.04046.x
This work was financially supported by grants from Science and Technology Commission of Shanghai Municipality (Grant No. 08JC1420800 and 09JC1415500), the National Basic Research Program (〈973〉 Program) of P.R. China (Grant No. 2005CB522704), Natural Science Foundation of China (Grant No. 30730034, 50732002, and 30900299) and Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures (Grant No. SKL200902).
- Issue published online: 5 JAN 2011
- Article first published online: 3 SEP 2010
- Manuscript No. 27864. Received April 16, 2010; approved July 12, 2010.
In this study, the hydroxyapatite/wollastonite (Ca10(PO4)6(OH)2/CaSiO3, HAp/CS) composite bioceramics with different weight ratio were fabricated. The effects of composite ratio on sintering behavior, microstructure, mechanical properties, bioactivity, degradability behavior and the bone marrow mesenchymal stem cells (MSC) response to the composites were investigated. When the weight ratio of CS increased, the linear shrinkage of the ceramics decreased, while the porosity increased. The bending strength of the composites could be regulated between 98.06 ± 3.27 and 221.30 ± 15.69 MPa, and increased apparently with the increase of the CS component amount. The elastic modulus of the sintered samples was about 14.88–18.95 GPa, which was similar to that of human cortical bone. The bioactivity of the composites was enhanced with increasing CS content. For composites with more than 30 wt% CS contents, the samples were completely covered by a layer of dense apatite only after 1 day soaking. The dissolution rate of the samples increased with the increase of CS content, which suggested that the degradability of the HAp/CS composite bioceramics could be tailored by adjusting the initial HAp/CS ratio. In addition, the proliferation of MSC on the composites was examined and the results showed that higher content of CS content in composites promoted cell proliferation. When the CS content in the composite increased to 30 wt%, the proliferation rate of MSC cells showed significant higher than that of pure HAp (P<0.05). Therefore, the HAp/CS composites with more than 30 wt% CS content might be promising candidates as load bearing, bioactive, and degradable biomaterials for hard tissue repair applications.