J. Ferreira—contributing editor
Effect of Disordered Structure of Boron-Containing Calcium Phosphates on their In Vitro Biodegradability
Article first published online: 14 MAR 2011
© 2011 The American Ceramic Society
Journal of the American Ceramic Society
Volume 94, Issue 8, pages 2656–2662, August 2011
How to Cite
Barheine, S., Hayakawa, S., Jäger, C., Shirosaki, Y. and Osaka, A. (2011), Effect of Disordered Structure of Boron-Containing Calcium Phosphates on their In Vitro Biodegradability. Journal of the American Ceramic Society, 94: 2656–2662. doi: 10.1111/j.1551-2916.2011.04400.x
This work was supported by the Deutsche Forschungsgemeinschaft DFG under the JSPS-DFG program (grant no. Ja 552/25-1) and by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science under the JSPS-DFG program.
- Issue published online: 9 AUG 2011
- Article first published online: 14 MAR 2011
- Manuscript No. 28184. Received June 14, 2010; approved December 23, 2010.
This study proposes a new guideline for designing biodegradable apatite ceramics. Boron-containing hydroxyapatite (BHAp) particles were prepared by a high-temperature solid-state reaction processing method and were characterized in terms of their chemical composition, apatite lattice defects and in vitro biodegradability. Solid-state nuclear magnetic resonance analysis showed that boron-incorporation into hydroxyapatite (HAp) derived by thermo-chemical reactions between borate and calcium phosphate phases led to disordered phases (BCaP) of a CaO–P2O5–B2O3–OH system covering the crystalline HAp core. X-ray diffraction analysis indicated that the BCaP phase must consist mainly of a crystalline oxyboroapatite (OBAp) phase. An in vitro biodegradability test showed that BHAp degraded quicker than HAp or β-tricalcium phosphate. The biodegradability of BHAp particles can be controlled by boron incorporation into a HAp lattice leading to the formation of a disordered OBAp phase.