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Synthesis and Bioactivity of Sol–Gel Derived Porous, Bioactive Glass Microspheres Using Chitosan as Novel Biomolecular Template


  • This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A110416).

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This article reports a novel, simple route for synthesis of sol–gel derived porous, bioactive glass (BG) microspheres using chitosan (CTS) as a biomolecular template in the acid-catalyzed sol–gel process. The use of CTS, which is a natural biocompatible polymer with a unique molecular structure, allowed the synthesis of BG microparticles with a spherical shape, 5–10 μm in size. Furthermore, pores with a size of 5–40 nm were created entirely throughout BG microspheres, which were formed by removing the network of CTS present initially in the CTS-BG composite microparticles via heat-treatment at 600°C for 2 h. These porous BG microspheres induced the vigorous precipitation of apatite crystals on their surface when immersed in simulated body fluid for 24 h, thus suggesting their excellent bioactivity .