Hyperechogenicity of the Substantia Nigra in Parkinson's Disease

Authors

  • Pavel Ressner MD,

    1. From the Department of Neurology, Palacky University Medical School and University Hospital, Olomouc, Czech Republic (PR, DŠ, PH, PK); Department of Neurology, University Hospital in Ostrava-Poruba, Ostrava-Poruba, Czech Republic (DŠ)
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  • David Školoudík MD,

    1. From the Department of Neurology, Palacky University Medical School and University Hospital, Olomouc, Czech Republic (PR, DŠ, PH, PK); Department of Neurology, University Hospital in Ostrava-Poruba, Ostrava-Poruba, Czech Republic (DŠ)
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  • Petr Hluštík MD, PhD,

    1. From the Department of Neurology, Palacky University Medical School and University Hospital, Olomouc, Czech Republic (PR, DŠ, PH, PK); Department of Neurology, University Hospital in Ostrava-Poruba, Ostrava-Poruba, Czech Republic (DŠ)
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  • Petr Kaňovský MD, PhD

    1. From the Department of Neurology, Palacky University Medical School and University Hospital, Olomouc, Czech Republic (PR, DŠ, PH, PK); Department of Neurology, University Hospital in Ostrava-Poruba, Ostrava-Poruba, Czech Republic (DŠ)
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Address correspondence to Pavel Ressner, MD, Neurologická klinika FN Olomouc, I.P. Pavlova 6, Olomouc, 77520, Czech Republic. E-mail: pavel.ressner@seznam.cz

ABSTRACT

Substantia nigra (SN) was assessed by transcranial sonography (TCS) in 47 Parkinson's disease (PD) patients and in 39 healthy volunteers. A semiquantitative echogenicity scale was created with arbitrary values ranging from 1 to 5, zones with grade ≥3 and larger than 0.19 cm2 were recorded as hyperechogenic SN. TCS examination of SN as a diagnostic test for PD in our study showed 87.2% sensitivity and 94.9% specificity.

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