Proton Magnetic Resonance Spectroscopy Detects a Relative Decrease of N-Acetylaspartate in the Hippocampus of Patients With Dementia With Lewy Bodies

Authors


  • Conflict of interest: None

Correspondence: Address correspondence to Meiping Ding MD, Department of Neurology, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, P.R. China. E-mail: yichen@mail.hz.zj.cn

Abstract

ABSTRACT

BACKGROUND AND PURPOSE

To characterize the cerebral metabolic changes in dementia with Lewy bodies patients.

METHODS

The metabolic ratios of NAA/Cr and Cho/Cr in bilateral hippocampus were determined by proton magnetic resonance spectroscopy in 8 patients and 8 age-matched healthy controls.

RESULTS

Dementia with Lewy bodies patients showed significantly lower NAA/Cr ratios in bilateral hippocampus, while the Cho/Cr ratio did not differ from the control group.

CONCLUSIONS

Our data show relatively decrease of N-acetylaspartate in the hippocampus of patients with early or intermediate stage DLB. Hence, damage of neurons seems to be an early alteration in DLB.

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