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High-Resolution Phased-Array MRI of the Human Brain at 7 Tesla: Initial Experience in Multiple Sclerosis Patients

Authors

  • Meredith Metcalf PhD,

    1. From the UCSF/UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA (MM, PM, SJN, DBV); Department of Radiology, University of California, San Francisco, CA (MM, DX, LC, RS, PM, SJN, DBV); Department of Neurology, University of California, San Francisco, CA, UCSF Advanced Imaging in Multiple Sclerosis Group, University of California, San Francisco, CA (DTO, DP); and Global Applied Science Laboratory, GE Healthcare Technologies, San Francisco, CA (DACK).
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  • Duan Xu PhD,

    1. From the UCSF/UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA (MM, PM, SJN, DBV); Department of Radiology, University of California, San Francisco, CA (MM, DX, LC, RS, PM, SJN, DBV); Department of Neurology, University of California, San Francisco, CA, UCSF Advanced Imaging in Multiple Sclerosis Group, University of California, San Francisco, CA (DTO, DP); and Global Applied Science Laboratory, GE Healthcare Technologies, San Francisco, CA (DACK).
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  • Darin T. Okuda MD,

    1. From the UCSF/UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA (MM, PM, SJN, DBV); Department of Radiology, University of California, San Francisco, CA (MM, DX, LC, RS, PM, SJN, DBV); Department of Neurology, University of California, San Francisco, CA, UCSF Advanced Imaging in Multiple Sclerosis Group, University of California, San Francisco, CA (DTO, DP); and Global Applied Science Laboratory, GE Healthcare Technologies, San Francisco, CA (DACK).
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  • Lucas Carvajal MS,

    1. From the UCSF/UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA (MM, PM, SJN, DBV); Department of Radiology, University of California, San Francisco, CA (MM, DX, LC, RS, PM, SJN, DBV); Department of Neurology, University of California, San Francisco, CA, UCSF Advanced Imaging in Multiple Sclerosis Group, University of California, San Francisco, CA (DTO, DP); and Global Applied Science Laboratory, GE Healthcare Technologies, San Francisco, CA (DACK).
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  • Radhika Srinivasan PhD,

    1. From the UCSF/UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA (MM, PM, SJN, DBV); Department of Radiology, University of California, San Francisco, CA (MM, DX, LC, RS, PM, SJN, DBV); Department of Neurology, University of California, San Francisco, CA, UCSF Advanced Imaging in Multiple Sclerosis Group, University of California, San Francisco, CA (DTO, DP); and Global Applied Science Laboratory, GE Healthcare Technologies, San Francisco, CA (DACK).
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  • Douglas A.C. Kelley PhD,

    1. From the UCSF/UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA (MM, PM, SJN, DBV); Department of Radiology, University of California, San Francisco, CA (MM, DX, LC, RS, PM, SJN, DBV); Department of Neurology, University of California, San Francisco, CA, UCSF Advanced Imaging in Multiple Sclerosis Group, University of California, San Francisco, CA (DTO, DP); and Global Applied Science Laboratory, GE Healthcare Technologies, San Francisco, CA (DACK).
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  • Pratik Mukherjee MD, PhD,

    1. From the UCSF/UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA (MM, PM, SJN, DBV); Department of Radiology, University of California, San Francisco, CA (MM, DX, LC, RS, PM, SJN, DBV); Department of Neurology, University of California, San Francisco, CA, UCSF Advanced Imaging in Multiple Sclerosis Group, University of California, San Francisco, CA (DTO, DP); and Global Applied Science Laboratory, GE Healthcare Technologies, San Francisco, CA (DACK).
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  • Sarah J. Nelson D.Rec.Nat.,

    1. From the UCSF/UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA (MM, PM, SJN, DBV); Department of Radiology, University of California, San Francisco, CA (MM, DX, LC, RS, PM, SJN, DBV); Department of Neurology, University of California, San Francisco, CA, UCSF Advanced Imaging in Multiple Sclerosis Group, University of California, San Francisco, CA (DTO, DP); and Global Applied Science Laboratory, GE Healthcare Technologies, San Francisco, CA (DACK).
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  • Daniel B. Vigneron PhD,

    1. From the UCSF/UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA (MM, PM, SJN, DBV); Department of Radiology, University of California, San Francisco, CA (MM, DX, LC, RS, PM, SJN, DBV); Department of Neurology, University of California, San Francisco, CA, UCSF Advanced Imaging in Multiple Sclerosis Group, University of California, San Francisco, CA (DTO, DP); and Global Applied Science Laboratory, GE Healthcare Technologies, San Francisco, CA (DACK).
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  • Daniel Pelletier MD

    1. From the UCSF/UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA (MM, PM, SJN, DBV); Department of Radiology, University of California, San Francisco, CA (MM, DX, LC, RS, PM, SJN, DBV); Department of Neurology, University of California, San Francisco, CA, UCSF Advanced Imaging in Multiple Sclerosis Group, University of California, San Francisco, CA (DTO, DP); and Global Applied Science Laboratory, GE Healthcare Technologies, San Francisco, CA (DACK).
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  • J Neuroimaging 2010;20:141-147.

Correspondence: Address correspondence to Daniel Pelletier, MD, UCSF Advanced Imaging in MS Laboratory, China Basin Landing, 185 Berry Street, Room 350, University of California, San Francisco, CA 94017. E-mail: daniel.pelletier@ucsf.edu.

ABSTRACT

Recent advancement for magnetic resonance imaging (MRI) involves the incorporation of higher-field strengths. Although imagers with higher magnetic field strengths were developed and tested in research labs, the direct application to patient MR studies have been extremely limited. Imaging at 7 Tesla (7T) affords advantages in signal-to-noise ratio and image contrast and resolution; however, these benefits can only be realized if the correct coils exist to capture the images. The objective of this study was to develop optimized high-resolution 7T MRI techniques using high sensitivity, specialized phased-array coils, for improved gray matter (GM) and white matter differentiation, in an effort to improve visualization of multiple sclerosis (MS) lesions in vivo. Twenty-three subjects were enrolled in this preliminary study, 17 with clinically definite MS (11 females, 6 males; mean age 43.4 years; range 22-64 years) and 6 healthy controls (2 females, 4 males; mean age 39.0 years; range 27-67 years). MR imaging of MS patients at 7T was demonstrated to be safe, well tolerated, and provided high-resolution anatomical images allowing visualization of structural abnormalities localized near or within the cortical layers. Clear involvement of the GM was observed with improved morphological detail in comparison to imaging at lower-field strength.

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