Disclosures: This work was supported by FAPESP.
Thalamic Volume and Dystonia in Machado–Joseph Disease
Article first published online: 3 FEB 2010
Copyright © 2010 by the American Society of Neuroimaging
Journal of Neuroimaging
Volume 21, Issue 2, pages e91–e93, April 2011
How to Cite
D’Abreu, A., França Jr, M. C., Yasuda, C. L., Souza, M. S.A., Lopes-Cendes, Í. and Cendes, F. (2011), Thalamic Volume and Dystonia in Machado–Joseph Disease. Journal of Neuroimaging, 21: e91–e93. doi: 10.1111/j.1552-6569.2010.00464.x
J Neuroimaging 2011;21:e91-e93.
- Issue published online: 3 FEB 2010
- Article first published online: 3 FEB 2010
- Acceptance: Received August 16, 2009, and in revised form October 27, 2009. Accepted for publication November 18, 2009.
- Machado– Joseph disease (MJD);
BACKGROUND AND PURPOSE
Neuropathological studies and one positron emission tomography study demonstrated involvement of the thalamus in Machado–Joseph disease (MJD), but a large series of patients has not been studied. Our objective was to perform an automated and a manual segmentation of the thalamus in patients with MJD.
We used the MarsBar volume of interest analysis toolbox to SPM2 and selected thalamic region of interests and we performed a t-test with Bonferroni's correction using SPM2 to compare patients to control. Next, we performed manual segmentation of the thalamus using the display software. Differences between patients and controls were analyzed by t-test. We also correlated manual thalamic volumes with clinical and genetic markers of the disease.
We observed decreased thalamic volumes in MJD when compared to controls using both methods of volumetric measurement. MJD patients with dystonia had smaller volumes than patients without dystonia.
We confirmed thalamic involvement in MJD patients. Patients with dystonia had smaller thalamic volumes than patients without dystonia. We observed a clinical–anatomical correlation, which suggests that different phenotypes of the disease present different primary or secondary targets of the disease.