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Dramatic Changes of a DWI Lesion in a Patient with Acute Ischemic Stroke Treated with IV t-PA


  • Conflict of Interest: None.

  • J Neuroimaging 2013;23:228-230.

Yuki Sakamoto, Kawasaki Medical School—Stroke Medicine, Matsushima 577, Kurashiki City 701–0192, Japan. E-mail:


A diffusion-weighted imaging (DWI) lesion changed dramatically in a hyperacute stroke case treated with intravenous tissue-plasminogen activator (IV t-PA). The initial hyperintense lesion on DWI disappeared completely immediately after IV t-PA treatment without improvement of neurological symptoms. However, the lesion reappeared 24 hours later. Successful thrombolysis can resolve DWI lesions but does not always improve the neurological symptoms.

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