Conflicts of Interest: The authors report no conflicts.
Clinical Investigative Study
White Matter Lesions Progression in Migraine with Aura: A Clinical and MRI Longitudinal Study
Article first published online: 23 JAN 2012
Copyright © 2012 by the American Society of Neuroimaging
Journal of Neuroimaging
Volume 23, Issue 1, pages 47–52, January 2013
How to Cite
Dinia, L., Bonzano, L., Albano, B., Finocchi, C., Del Sette, M., Saitta, L., Castellan, L., Gandolfo, C. and Roccatagliata, L. (2013), White Matter Lesions Progression in Migraine with Aura: A Clinical and MRI Longitudinal Study. Journal of Neuroimaging, 23: 47–52. doi: 10.1111/j.1552-6569.2011.00643.x
J Neuroimaging 2013;23:47-52.
- Issue published online: 16 JAN 2013
- Article first published online: 23 JAN 2012
- Acceptance: Received January 24, 2011, and in revised form June 16, 2011. Accepted for publication June 18, 2011.
- migraine with aura;
- white matter lesions
To prospectively evaluate longitudinal changes in white matter lesions (WMLs) in migraineurs with aura, by magnetic resonance imaging (MRI), and to correlate WMLs modifications with patients’ clinical characteristics.
Forty-one consecutive migraineurs with aura were followed for a mean time of 33.2 months. Patients underwent MRI at baseline and follow-up and were evaluated for cerebrovascular risk factors. Presence of WMLs on MRI was assessed by two neuroradiologists.
WMLs were present in 26 subjects (63.4%) at baseline MRI. At follow-up a total of 8 patients had new WMLs (19.5%). There was a significant correlation between aura duration and number of new WMLs, and between the number of migraine attacks with aura and new WMLs.
Our study demonstrates that in migraine with aura WMLs number can progress over time and suggests an association between aura features and WMLs progression. Studies with a higher number of patients are required to confirm these findings.