Disclosure: The authors have reported no conflicts of interest.
Clinical Investigative Study
Diffusion Tensor Imaging of Basal Ganglia and Thalamus in Amyotrophic Lateral Sclerosis
Article first published online: 24 JAN 2012
Copyright © 2012 by the American Society of Neuroimaging
Journal of Neuroimaging
Volume 23, Issue 3, pages 368–374, July 2013
How to Cite
Sharma, K. R., Sheriff, S., Maudsley, A. and Govind, V. (2013), Diffusion Tensor Imaging of Basal Ganglia and Thalamus in Amyotrophic Lateral Sclerosis. Journal of Neuroimaging, 23: 368–374. doi: 10.1111/j.1552-6569.2011.00679.x
Presented as an abstract in part at the 61st AAN meeting, April 25th–May 2, 2009, Seattle, WA, USA.
J Neuroimaging 2013;23:368-374.
- Issue published online: 2 JUL 2013
- Article first published online: 24 JAN 2012
- Acceptance: Received April 17, 2011, and in revised form August 12, 2011. Accepted for publication August 18, 2011.
- amyotrophic lateral sclerosis;
- basal ganglia;
To assess the involvement of basal ganglia and thalamus in patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor imaging (DTI) method.
Fourteen definite-ALS patients and 12 age-matched controls underwent whole brain DTI on a 3T scanner. Mean-diffusivity (MD) and fractional anisotropy (FA) were obtained bilaterally from the basal ganglia and thalamus in the regions-of-interest (ROIs).
The MD was significantly higher (P < .02) in basal ganglia and thalamus in patients with ALS compared with controls. Correspondingly, the FA was significantly lower (P < .02) in these structures, except in caudate (P = .04) and putamen (P = .06) in patients compared with controls. There were mild to strong correlations (r = .3−.7) between the DTI measures of basal ganglia and finger-tap, foot-tap, and lip-and-tongue movement rate.
The increased MD in basal ganglia and thalamus and decreased FA in globus pallidus and thalamus are indicative of neuronal loss or dysfunction in these structures.