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The concept of the mother and her newborn as mutual psychophysiological caregivers is discussed, with references to the supporting literature. Facilitating self-regulatory mother-newborn interaction from immediately after delivery onward is presented as the optimum approach to enhancing the benefits of mutual caregiving, and this approach is contrasted with current practice. The author also addresses reasons commonly given for denying self-regulatory mother-infant interaction and outlines relevant ongoing research activity at her institution.