Standard and Higher Doses of Atropine in a Canine Model of Pulse less Electrical Activity
Article first published online: 29 SEP 2008
© 1995 Society for Academic Emergency Medicine
Academic Emergency Medicine
Volume 2, Issue 12, pages 1034–1041, December 1995
How to Cite
Behnke, D. J. D., Swart, G. L., Spreng, D. and Aufderheide, T. P. (1995), Standard and Higher Doses of Atropine in a Canine Model of Pulse less Electrical Activity. Academic Emergency Medicine, 2: 1034–1041. doi: 10.1111/j.1553-2712.1995.tb03145.x
- Issue published online: 29 SEP 2008
- Article first published online: 29 SEP 2008
- Received: February 24, 1995; accepted: March 31, 1595.
- cardiac arrest;
Objective: To determine whether standard or increased doses of atropine improve the return of spontaneous circulation (ROSC) rate in a canine model of pulseless electrical activity (PEA).
Methods: A prospective, controlled, blinded laboratory investigation was performed using an asphyxial canine cardiac arrest model. After the production of asphyxial PEA, 75 dogs remained in untreated PEA for 10 minutes and then were randomized to receive placebo (group 1) or one of four doses of atropine (group 2, 0.04 mg/kg; group 3, 0.1 mg/kg; group 4, 0.2 mg/kg; group 5, 0.4 mg/kg). All the animals received mechanical external CPR and epinephrine (0.02 mg/kg every 3 minutes) throughout resuscitation.
Results: The ROSC rates were not significantly different between the groups (group 1, 73%; group 2, 67%; group 3. 40%; group 4, 47%; group 5, 27%; p = 0.06). The heart rates and hemodynamics during resuscitation were not significantly different between the groups.
Conclusion: In this canine model of asphyxial PEA cardiac arrest, standard-dose atropine did not improve ROSC rates, compared with placebo. Increasing doses of atropine tended to decrease ROSC rates, compared with placebo and standard-dose atropine.