Effectiveness of 50% Nitrous Oxide/50% Oxygen during Laceration Repair in Children
Version of Record online: 28 JUN 2008
Academic Emergency Medicine
Volume 5, Issue 2, pages 112–117, February 1998
How to Cite
Burton, J. H., Auble, T. E. and Fuchs, S. M. (1998), Effectiveness of 50% Nitrous Oxide/50% Oxygen during Laceration Repair in Children. Academic Emergency Medicine, 5: 112–117. doi: 10.1111/j.1553-2712.1998.tb02594.x
- Issue online: 28 JUN 2008
- Version of Record online: 28 JUN 2008
- Received June 3, 1997; reveision received: July 22, 1997; accepted: August 2, 1997; updated: September 10, 1997.
- pediatric sedation;
- emergency department
Objective: To determine the effect of an inhaled 50% nitrous oxide/50% oxygen mixture on measures of observed anxiety in children during laceration repair.
Methods: A prospective, randomized, placebo-controlled, double-blind comparison of an inhaled 50% nitrous oxide/50% oxygen mixture (treatment group) with 100% oxygen (control group) during repair of lacerations was performed. The study population was a convenience sample of children aged 2–7 years in an urban pediatric ED. The primary outcome variable was the change in scores before and during laceration repair with a 10-point modified Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) assessment. The secondary outcome variable was a 4-point anxiety scale measured before and during the procedure.
Results: Thirty patients were entered into the study. Seventeen children inhaled the 50% nitrous oxide/oxygen mixture and 13 inhaled 100% oxygen during laceration repair. There was no statistically significant difference in initial CHEOPS and anxiety scores between the 2 groups (p = 0.687 and 0.809, respectively). The median CHEOPS scores in the treatment group decreased by 5 points, while those of the control patients increased by 3 (p < 0.001). The median anxiety scores in the treatment population decreased by 1 point, with an increase of 1 for the control patients (p < 0.001).
Conclusion: Administration of a 50% nitrous oxide/50% oxygen mixture to children during their laceration repair resulted in a significant decrease in measures of anxiety when compared with inhalation of 100% oxygen.