• 1
    The Pediatric Emergency Research Canada. Available at: Accessed May 23, 2007.
  • 2
    Klassen T., Feldman M., Watters L., Sutcliffe T., Rowe C. Nebulized budesonide for children with mild-to-moderate croup N Engl J Med 1994;331:285289.
  • 3
    Bjornson CL, Klassen TP, Williamson J., et al. A randomized trial of a single dose of oral dexamethasone for mild croup N Engl J Med 2004;351:13061313.
  • 4
    Johnson D., Jacobson S., Edney P., Hadfield P., Mundy M., Schuh S. A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup N Engl J Med 1998;339:498503.
  • 5
    Klassen TP, Craig WR, Moher D., et al. Nebulized budesonide and oral dexamethasone for treatment of croup: a randomized controlled trial JAMA 1998;279:16291632.
  • 6
    Klassen TP, Watters LK, Feldman ME, et al. The efficacy of nebulized budesonide in dexamethasone-treated outpatients with croup Pediatrics 1996;97:463466.
  • 7
    Ausejo M., Saenz A., Pham B., et al. The effectiveness of glucocorticoides in treating croup: meta-analysis Br Med J 1999;319:595600.
  • 8
    Russell K., Wiebe N., Saenz A., et al. Glucocorticoids for croup Cochrane Database Syst Rev 2004;1 CD001955.
  • 9
    Ausejo M., Saenz A., Pham B., et al. Glucocorticoids for croup Cochrane Database Syst Rev 2000;2 CD001955.
  • 10
    Klassen TP, Rowe PC, Sutcliffe T., Ropp LJ, McDowell IW, Li MM. Randomized trial of salbutamol in acute bronchiolitis J Pediatr 1991;118:807811.
  • 11
    Menon K., Sutcliffe T., Klassen TP. A randomized trial comparing the efficacy of epinephrine with salbutamol in the treatment of acute bronchiolitis J Pediatr 1995;126:10041007.
  • 12
    Hartling L., Wiebe N., Russell K., Patel H., Klassen TP. Epinephrine for bronchiolitis Cochrane Database Syst Rev 2004;1 CD003123.
  • 13
    Hartling L., Wiebe N., Russell K., Patel H., Klassen TP. A meta-analysis of randomized controlled trials evaluating the efficacy of epinephrine for the treatment of acute viral bronchiolitis Arch Pediatr Adolesc Med 2003;157:957964.
  • 14
    Klassen TP, Sutcliffe T., Watters LK, Wells GA, Allen UD, Li MM. Dexamethasone in salbutamol-treated inpatients with acute bronchiolitis: a randomized, controlled trial J Pediatr 1997;130:191196.
  • 15
    Bulloch B., Neto G., Plint A., et al. Validation of the Ottawa Knee Rule in children: a multicenter study Ann Emerg Med 2003;42:4855.
  • 16
    Plint AC, Bulloch B., Osmond MH, et al. Validation of the Ottawa Ankle Rules in children with ankle injuries Acad Emerg Med 1999;6:10051009.
  • 17
    Klassen TP, Reed MH, Stiell IG, et al. Variation in utilization of computed tomography scanning for the investigation of minor head trauma in children: a Canadian experience Acad Emerg Med 2000;7:739744.
  • 18
    Osmond MH, Klassen TP, Stiell IG, et al. A clinical decision rule for the use of CT head in children with minor head injury Acad Emerg Med 2004;11:449450.
  • 19
    Osmond MH, Klassen TP, Stiell IG, et al. Interobserver agreement in the assessment of children with minor head injury[abstract] Acad Emerg Med 2004;11:572.
  • 20
    Schuh S., Johnson DW, Stephens D., Callahan S., Winders P., Canny GJ. Comparison of albuterol delivered by a metered dose inhaler with spacer versus a nebulizer in children with mild acute asthma J Pediatr 1999;135:2227.
  • 21
    Kozyrskyj AL, Hildes-Ripstein GE, Longstaffe SE, et al. Treatment of acute otitis media with shortened course of antibiotics: a meta-analysis JAMA 1998;279:17361742.
  • 22
    Government of Canada. Canadian Institutes of Health Research. Available at: Accessed May 23, 2007.
  • 23
    Tugwell P., Bennett KJ, Sackett DL, Haynes RB. The measurement iterative loop: a framework for the critical appraisal of need, benefits and costs of health interventions J Chronic Dis 1985;38:339351.
  • 24
    Tugwell P., Bombardier C. Methodologic issues in international rheumatologic clinical epidemiology J Rheumatol 1983;10(Suppl 10):6567.
  • 25
    Bennett KJ, Tugwell P. Iterative loop gives framework for assessing technology Dimens Health Serv 1986;63:6871.
  • 26
    Advisory Committee on Cancer Control, National Cancer Institute of Canada Bridging research to action: a framework and decision-making process for cancer control CMAJ 1994;151:11411146.
  • 27
    Brownson RC, Newschaffer CJ. Policy research for disease prevention: challenges and practical recommendations Am J Public Health 1997;87:735739.
  • 28
    Geelhoed G. Sixteen years of croup in a western Australian teaching hospital: effects of routine steroid treatment Ann Emerg Med 1996;28:621626.
  • 29
    Segal AO, Crighton EJ, Moineddin R., Mamdani M., Upshur RE. Croup hospitalizations in Ontario: a 14-year time-series analysis Pediatrics 2005;116:5155.
  • 30
    Wennberg JE. Small area analysis and the medical case outcome problem. Conference Proceedings Research Methodology: Strengthening Causal Interpretations of Nonexperimental Data. Rockville, MD : Agency for Health Care Policy and Research, US Department of Health, 1990.
  • 31
    To T., Dick P., Young W. Hospitalization rates of children with croup in Ontario Paediatr Child Health 1996;1:103108.
  • 32
    Johnson D., Craig W., Brant R., Mitton C., Svenson B., Klassen T. A cluster randomized controlled trial comparing three methods of disseminating practice guidelines for children with croup BMC Implement Sci 2006;1:10Available /content/1/1/10 2006 Accessed May 23, 2007.
  • 33
    Ministry of Health and Long-term Care, Ontario. Improved Clinical Effectiveness through Behavioural Research Group (ICEBeRG). Available at: Accessed May 23, 2007.
  • 34
    Klassen T., Grimshaw J., Scott-Findlay S., Bialy L. Utilizing knowledge translation in an iterative paradigm to improve outcomes for ill and injured children in emergency departments: a Canadian Institutes for Health Research Team Grant. Presented at the 2006 Knowledge Utilization Conference, Minneapolis, MN.
  • 35
    Eccles M., Grimshaw J., Walker A., Johnston M., Pitts N. Changing the behaviour of healthcare professionals: the use of theory in promoting the uptake of research findings J Clin Epidemiol 2005;58:107112.
  • 36
    The Improved Clinical Effectiveness through Behavioral Research Group (ICEBeRG). Designing theoretically-informed implementation interventions Implement Sci 2006;1:4.
  • 37
    Grimshaw J., Zwarenstein M., Tetroe J., et al. Looking inside the black box: a theory based process evaluation alongside a randomised controlled trial of printed educational materials (The Ontario Printed Educational Message (OPEM)) Trial [registration number ISRCTN72772651] Implement Sci 2007 (in press).
  • 38
    Donaldson C., Currie G., Mitton C. Cost effectiveness analysis in health care: contraindications BMJ 2002;325:891894.
  • 39
    Drummond MF, Davies L. Economic analysis alongside clinical trials. Revisiting the methodological issues Int J Technol Assess Health Care 1991;7:561573.
  • 40
    Ramsey SD, McIntosh M., Sullivan SD. Design issues for conducting cost-effectiveness analyses alongside clinical trials Annu Rev Public Health 2001;22:129141.
  • 41
    Wordsworth S., Ludbrook A., Caskey F., Macleod A. Collecting unit cost data in multicentre studies. Creating comparable methods Eur J Health Econ 2005;6:3844.
  • 42
    Donaldson C., Hundley V., McIntosh E. Using economic evaluation alongside clinical trials: why we cannot choose the evaluation techniques in advance Health Econ Lett 1995;5:267269.
  • 43
    Reed SD, Anstrom KJ, Bakhai A., et al. Conducting economic evaluations alongside multinational clinical trials: toward a research consensus Am Heart J 2005;149:434443.
  • 44
    Sculpher M. Evaluating the cost-effectiveness of interventions designed to increase the utilisation of evidence-based guidelines Fam Pract 2000;17:S26S31.
  • 45
    Mason J., Freemantle N., Nazereth I., Eccles M., Haines A., Drummond M. When is it cost effective to change the behavior of health professionals? JAMA 2001;29:8892.
  • 46
    Vale L., Thomas R., MacLennan G., Grimshaw J. Systematic review of economic evaluations and cost analyses of guideline implementation strategies Eur J Health Econ 2007;8:111121.
  • 47
    Lang E., Wyer P., Haynes B. Knowledge translation: closing the evidence-to-practice gap Ann Emerg Med 2007;49:355363.
  • 48
    Grol R. Successes and failures in the implementation of evidence-based guidelines for clinical practice Med Care 2001;39:11461154.
  • 49
    Schuster MA, McGlynn EA, Brook RH. How good is the quality of health care in the United States? 1998 Milbank Q 2005;83:843895.
  • 50
    Grimshaw JM, Thomas RE, MacLennan G., et al. Effectiveness and efficiency of guideline dissemination and implementation strategies Health Technol Assess 2004;8:172.
  • 51
    Grimshaw JM, Shirran L., Thomas RE, et al. Changing provider behavior: an overview of systematic reviews of interventions Med Care 2001;39(Suppl 2):II2II45.
  • 52
    Bero LA, Grilli R., Grimshaw JM, Harvey E., Oxman AD, Thomson MA. Closing the gap between research and practice: an overview of systematic reviews of interventions to promote the implementation of research findings BMJ 1998;317:465468.
  • 53
    Oxman A., Thomson MA, Davis DA, Haynes RB. No magic bullets: a systematic review of 102 strategies to improve professional practice CMAJ 1995;153:14231431.
  • 54
    Zwarentein M., Reeves S. Knowledge translation and interprofessional collaboration: where the rubber of evidence-based care hits the road of teamwork J Contin Educ Health Prof 2006;26:4654.
  • 55
    Dault M., Lomas J., Barer M. Listening for Directions II: National Consultation on Health Services and Policy Issues for 2004-2007. Canadian Health Services Foundation and Institute of Health Services and Policy Research, Canadian Institutes of Health Research, 2004. Available at: http:www.cihr-irsc.gc.caedocumentslistening_for_direction_e.pdf Accessed May 23, 2007.