• 1
    Schuchat A, Robinson K, Wenger JD, et al. Bacterial meningitis in the United States in 1995. Active Surveillance Team. N Engl J Med. 1997; 337:9706.
  • 2
    Haddy RI, Perry K, Chacko CE, et al. Comparison of incidence of invasive Streptococcus pneumoniae disease among children before and after introduction of conjugated pneumococcal vaccine. Pediatr Infect Dis J. 2005; 24:3203.
  • 3
    Nigrovic LE, Kuppermann N, Malley R. Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era. Pediatrics. 2002; 110:7129.
  • 4
    Geiseler PJ, Nelson KE, Levin S, Reddi KT, Moses VK. Community-acquired purulent meningitis: a review of 1,316 cases during the antibiotic era, 1954-1976. Rev Infect Dis. 1980; 2:72545.
  • 5
    Wald ER, Kaplan SL, Mason EO Jr, et al. Dexamethasone therapy for children with bacterial meningitis. Meningitis Study Group. Pediatrics. 1995; 95:218.
  • 6
    Marton KI, Gean AD. The spinal tap: a new look at an old test. Ann Intern Med. 1986; 104:8408.
  • 7
    Aronin SI, Peduzzi P, Quagliarello VJ. Community-acquired bacterial meningitis: risk stratification for adverse clinical outcome and effect of antibiotic timing. Ann Intern Med. 1998; 129:8629.
  • 8
    Auburtin M, Wolff M, Charpentier J, et al. Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study. Crit Care Med. 2006; 34:275865.
  • 9
    Lepur D, Barsic B. Community-acquired bacterial meningitis in adults: antibiotic timing in disease course and outcome. Infection. 2007; 35:22531.
  • 10
    Proulx N, Frechette D, Toye B, Chan J, Kravcik S. Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM 2005; 98:2918.
  • 11
    Miner JR, Heegaard W, Mapes A, Biros M. Presentation, time to antibiotics, and mortality of patients with bacterial meningitis at an urban county medical center. J Emerg Med. 2001; 21:38792.
  • 12
    Bonsu BK, Harper MB. Differentiating acute bacterial meningitis from acute viral meningitis among children with cerebrospinal fluid pleocytosis: a multivariable regression model. Pediatr Infect Dis J. 2004; 23:5117.
  • 13
    Nigrovic LE, Kuppermann N, Macias CG, et al. Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. JAMA. 2007; 297:5260.
  • 14
    Hoen B, Viel JF, Paquot C, Gerard A, Canton P. Multivariate approach to differential diagnosis of acute meningitis. Eur J Clin Microbiol Infect Dis. 1995; 14:26774.
  • 15
    Leblebicioglu H, Esen S, Bedir A, Gunaydin M, Sanic A. The validity of Spanos’ and Hoen’s models for differential diagnosis of meningitis. Eur J Clin Microbiol Infect Dis. 1996; 15:2524.
  • 16
    Spanos A, Harrell FE Jr, Durack DT. Differential diagnosis of acute meningitis. An analysis of the predictive value of initial observations. JAMA. 1989; 262:27007.
  • 17
    Baty V, Viel JF, Schuhmacher H, Jaeger F, Canton P, Hoen B. Prospective validation of a diagnosis model as an aid to therapeutic decision-making in acute meningitis. Eur J Clin Microbiol Infect Dis. 2000; 19:4226.
  • 18
    Freedman SB, Marrocco A, Pirie J, Dick PT. Predictors of bacterial meningitis in the era after Haemophilus influenzae. Arch Pediatr Adolesc Med. 2001; 155:13016.
  • 19
    Oostenbrink R, Oostenbrink JB, Moons KG, et al. Application of a diagnostic decision rule in children with meningeal signs: a cost-minimization study. Int J Technol Assess Health Care. 2003; 19:698704.
  • 20
    Dubos F, Lamotte B, Bibi-Triki F, et al. Clinical decision rules to distinguish between bacterial and aseptic meningitis. Arch Dis Child. 2006; 91:64750.
  • 21
    Hastie T, Tibshirani R, Friedman JH. The Elements of Statistical Learning: Data Mining, Inference, and Prediction: With 200 Full-Color Illustrations. Springer Series in Statistics: Corrected Print. New York, NY: Springer, 2002.
  • 22
    Harrell FE. Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis. Springer Series in Statistics. New York, NY: Springer, 2001.
  • 23
    Justice AC, Covinsky KE, Berlin JA. Assessing the generalizability of prognostic information. Ann Intern Med. 1999; 130:51524.
  • 24
    Altman DG, Royston P. What do we mean by validating a prognostic model? Stat Med. 2000; 19:45373.
  • 25
    Stiell IG, Bennett C. Implementation of clinical decision rules in the emergency department. Acad Emerg Med. 2007; 14:9559.
  • 26
    Hosmer DW, Lemeshow S. Applied Logistic Regression. Wiley Series in Probability and Statistics. Texts and References Section, 2nd ed. New York, NY: Wiley, 2000.
  • 27
    Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem. 1993; 39:56177.
  • 28
    Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982; 143:2936.
  • 29
    Swets JA. Measuring the accuracy of diagnostic systems. Science. 1988; 240:128593.
  • 30
    Gallagher EJ. Clinical utility of likelihood ratios. Ann Emerg Med. 1998; 31:3917.
  • 31
    Jaeschke R, Guyatt GH, Sackett DL. Users’ guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group. JAMA. 1994; 271:7037.
  • 32
    Seehusen DA, Reeves MM, Fomin DA. Cerebrospinal fluid analysis. Am Fam Physician. 2003; 68:11038.
  • 33
    Gendrel D, Raymond J, Assicot M, et al. Measurement of procalcitonin levels in children with bacterial or viral meningitis. Clin Infect Dis. 1997; 24:12402.
  • 34
    Shohet I, Shahar E, Meyerovich J, Barzilay Z. Diagnosis of bacterial meningitis in previously treated children. South Med J. 1985; 78:299301.
  • 35
    Mandell GL, Douglas RG, Bennett JE, Dolin R. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 5th ed. Philadelphia, PA: Churchill Livingstone, 2000.