The authors’ microcirculation research has been supported by grants from the Emergency Medicine Foundation and the American Heart Association (0530152N) to Dr. Trzeciak. Dr. Trzeciak is now supported by a grant from the National Institutes of Health/National Institute of General Medical Sciences (K23GM083211).
Resuscitating the Microcirculation in Sepsis: The Central Role of Nitric Oxide, Emerging Concepts for Novel Therapies, and Challenges for Clinical Trials
Version of Record online: 17 APR 2008
© 2008 by the Society for Academic Emergency Medicine
Academic Emergency Medicine
Volume 15, Issue 5, pages 399–413, May 2008
How to Cite
Trzeciak, S., Cinel, I., Phillip Dellinger, R., Shapiro, N. I., Arnold, R. C., Parrillo, J. E., Hollenberg, S. M. and on behalf of the Microcirculatory Alterations in Resuscitation and Shock (MARS) Investigators (2008), Resuscitating the Microcirculation in Sepsis: The Central Role of Nitric Oxide, Emerging Concepts for Novel Therapies, and Challenges for Clinical Trials. Academic Emergency Medicine, 15: 399–413. doi: 10.1111/j.1553-2712.2008.00109.x
Dr. Trzeciak will receive material support (drug and delivery system) from INO Therapeutics for a forthcoming investigator-initiated randomized clinical trial of inhaled nitric oxide (INO) to augment microcirculatory blood flow in sepsis resuscitation. Dr. Trzeciak has received research support from Eli Lilly for a multicenter clinical trial of the effect of recombinant human activated protein C (rhAPC) on global and microcirculatory perfusion indices in sepsis. Dr. Dellinger receives research support from INO Therapeutics for an investigator-initiated pilot study of INO in patients with sepsis.
- Issue online: 17 APR 2008
- Version of Record online: 17 APR 2008
- Received October 31, 2007; revision received February 1, 2008; accepted February 2, 2008.
Data Supplement S1. Our technique for sublingual microcirculatory image acquisition, processing, and analysis (PDF document).
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