Forensic DNA Analysis on Microfluidic Devices: A Review

  1. Katie M. Horsman Ph.D.1,
  2. Joan M. Bienvenue Ph.D.1,
  3. Kiev R. Blasier B.S.1,
  4. James P. Landers Ph.D.1,2,3

Article first published online: 6 JUN 2007

DOI: 10.1111/j.1556-4029.2007.00468.x

Issue

Journal of Forensic Sciences

Journal of Forensic Sciences

Volume 52, Issue 4, pages 784–799, July 2007

Additional Information

How to Cite

Horsman, K. M., Bienvenue, J. M., Blasier, K. R. and Landers, J. P. (2007), Forensic DNA Analysis on Microfluidic Devices: A Review. Journal of Forensic Sciences, 52: 784–799. doi: 10.1111/j.1556-4029.2007.00468.x

Author Information

  1. 1

    Department of Chemistry, University of Virginia, Charlottesville, VA 22904.

  2. 2

    Department of Pathology, University of Virginia Medical School, Charlottesville, VA 22904.

  3. 3

    Department of Mechanical Engineering, University of Virginia, Charlottesville, VA 22904.

*Additional information and reprint requests: James P. Landers, Ph.D. Department of Chemistry University of Virginia Box 400319 Charlottesville, VA 22901 E-mail: landers@virginia.edu

Publication History

  1. Issue published online: 6 JUN 2007
  2. Article first published online: 6 JUN 2007
  3. Received 20 May 2006; and in revised form 30 Sept. 2006, 14 Jan. 2007; accepted 15 Jan. 2007; published 24 May 2007.

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Keywords:

  • forensic science;
  • DNA typing;
  • microfluidics;
  • microchip technology

Abstract:  The advent of microfluidic technology for genetic analysis has begun to impact forensic science. Recent advances in microfluidic separation of short-tandem-repeat (STR) fragments has provided unprecedented potential for improving speed and efficiency of DNA typing. In addition, the analytical processes associated with sample preparation––which include cell sorting, DNA extraction, DNA quantitation, and DNA amplification––can all be integrated with the STR separation in a seamless manner. The current state of these microfluidic methods as well as their advantages and potential shortcomings are detailed. Recent advances in microfluidic device technology, as they pertain to forensic DNA typing, are discussed with a focus on the forensic community.

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