Presented at the 60th Annual Meeting of the American Academy of Forensic Sciences, Feb. 18–23, 2008, in Washington, DC.
Morbidity Involving the Hallucinogenic Designer Amines MDA and 2C-I*
Article first published online: 23 OCT 2009
© 2009 American Academy of Forensic Sciences
Journal of Forensic Sciences
Volume 54, Issue 6, pages 1485–1487, November 2009
How to Cite
Drees, J. C., Stone, J. A. and Wu, A. H. B. (2009), Morbidity Involving the Hallucinogenic Designer Amines MDA and 2C-I. Journal of Forensic Sciences, 54: 1485–1487. doi: 10.1111/j.1556-4029.2009.01199.x
- Issue published online: 23 OCT 2009
- Article first published online: 23 OCT 2009
- Received 8 July 2008; and in revised form 19 Dec. 2008; accepted 20 Dec. 2008.
- forensic science;
- liquid chromatography–tandem mass spectrometry;
- hemorrhagic stroke;
Abstract: A case is presented of a 39-year-old woman who suffered severe debilitation because of a hemorrhagic stroke in the context of substance abuse. The patient presented to the emergency room with rapidly diminishing mental status, hypertension, and vasoconstriction; her friends provided a history of ingestion of cocaine, 3,4-methylenedioxymethamphetamine (MDMA), and 2C-I, a novel designer amine. A multi-targeted LC-MS/MS method for sympathomimetic amines and related drugs in urine detected and quantified 2C-I and MDA, while ruling out MDMA. The cause of the stroke was determined to be an underlying cerebrovascular abnormality called Moyamoya, secondary to substance abuse. In clinical laboratories, gas chromatography–mass spectrometry or liquid chromatography–tandem mass spectrometry (LC-MS/MS) confirmation of a positive amphetamine immunoassay is usually directed only towards amphetamine, methamphetamine, MDMA and MDA. This report demonstrates the utility of testing for a wider menu of compounds using LC-MS/MS in order to better characterize the prevalence and toxicities of novel amines such as 2C-I.