Study: The Lack of Significant Association of the Catechol-O-Methyl Transferase (COMT) Gene Polymorphism in Violent Offenders with Mental Retardation
Article first published online: 5 NOV 2009
© 2009 American Academy of Forensic Sciences
Journal of Forensic Sciences
Volume 55, Issue 1, pages 225–228, January 2010
How to Cite
Isir, A. B., Dai, A. I., Nacak, M. and Gorucu, S. (2010), Study: The Lack of Significant Association of the Catechol-O-Methyl Transferase (COMT) Gene Polymorphism in Violent Offenders with Mental Retardation. Journal of Forensic Sciences, 55: 225–228. doi: 10.1111/j.1556-4029.2009.01205.x
- Issue published online: 4 JAN 2010
- Article first published online: 5 NOV 2009
- Received 25 May 2008; and in revised form 20 Dec. 2008; accepted 21 Dec. 2008.
- forensic science;
- catechol O-methyl transferase;
- DNA polymorphism;
- polymerase chain reaction;
- mental retardation
Abstract: Little is known about criminality of cognitively impaired people and also there have been no reports on the relationship between catechol-O-methyl transferase (COMT) and committed Mental Retardation (MR) subjects. In the present study, the association between committed (violent offences) MR subjects and genetic variants of COMT were investigated by using polymerase chain reaction and based restriction fragment length polymorphism methods. During 6 years of follow-up, 36 violent offenders with mild MR were investigated. Thirty-six control volunteers were included in the study as a control group. H/L polymorphism of the COMT gene was investigated in these two groups. In conclusion, the COMT gene genotype distribution and allele frequency is not significantly different between the two groups (p > 0.05). This result suggests that the H/L polymorphism of the COMT gene does not show an association with the potential of “commits-violent offense” of Turkish subjects with mental retardation, compared with control group.