This research has been generously funded by: NSF-REU CHE-0648843, Zyvex Industrial Grant GN0001371, and UNT Faculty Research Grant G34267.
Nanomanipulation-Coupled Nanospray Mass Spectrometry Applied to the Extraction and Analysis of Trace Analytes Found on Fibers*
Article first published online: 28 APR 2010
© 2010 American Academy of Forensic Sciences
Journal of Forensic Sciences
Volume 55, Issue 5, pages 1218–1221, September 2010
How to Cite
Ledbetter, N. L., Walton, B. L., Davila, P., Hoffmann, W. D., Ernest, R. N. and Verbeck, G. F. (2010), Nanomanipulation-Coupled Nanospray Mass Spectrometry Applied to the Extraction and Analysis of Trace Analytes Found on Fibers. Journal of Forensic Sciences, 55: 1218–1221. doi: 10.1111/j.1556-4029.2010.01406.x
- Issue published online: 1 SEP 2010
- Article first published online: 28 APR 2010
- Received 20 Sept. 2008; and in revised form 15 June 2009; accepted 4 July 2009.
- forensic science;
- trace analysis;
- mass spectrometry
Abstract: This article presents the novel instrumentation of nanomanipulation coupled to nanospray ionization-mass spectrometry, which is used to directly probe trace analytes found on individual fibers. The low detection limits and sample volumes associated with nanospray ionization-mass spectrometry make it the ideal instrument to implement for trace analysis. Nanospray ionization-mass spectrometry, coupled with the nanomanipulator, allows for the direct probing of trace particulates on fibers. The technique is demonstrated by dissolving an electrostatic particle of cocaine from a fiber, collecting the analyte solution in a nanospray tip, and transferring the tip directly to the mass spectrometer to complete analysis. The utility of this technique is evident through the minimal sample preparation and short analysis time. The use of nanomanipulation coupled to nanospray ionization-mass spectrometry could improve on current trace particulate analysis by reducing both detection limits and sample size required to complete analysis.