Acute Arsenic Poisoning: Clinical, Toxicological, Histopathological, and Forensic Features
Article first published online: 15 OCT 2010
© 2010 American Academy of Forensic Sciences
Journal of Forensic Sciences
Volume 56, Issue Supplement s1, pages S275–S279, January 2011
How to Cite
Tournel, G., Houssaye, C., Humbert, L., Dhorne, C., Gnemmi, V., Bécart-Robert, A., Nisse, P., Hédouin, V., Gosset, D. and Lhermitte, M. (2011), Acute Arsenic Poisoning: Clinical, Toxicological, Histopathological, and Forensic Features. Journal of Forensic Sciences, 56: S275–S279. doi: 10.1111/j.1556-4029.2010.01581.x
- Issue published online: 3 JAN 2011
- Article first published online: 15 OCT 2010
- Received 15 Apr. 2009; and in revised form 10 Dec. 2009; accepted 12 Dec. 2009.
- forensic science;
- inductively coupled plasma mass spectrometry;
Abstract: This report describes a suicide case by acute arsenic intoxication via intravenous injection. A 30-year-old woman injected arsenic As (V) (sodium arseniate disodique: Disodium Hydrogena Arsenik RP) in a successful suicide attempt. Three hours following administration, the woman developed severe digestive symptoms. She was admitted to a hospital and transferred to the intensive care unit within 12 h of the massive administration of arsenic. Despite therapeutic efforts, over the next 2 h she developed multiorgan failure and died. A postmortem examination was performed. Pulmonary edema and congestion of liver were apparent. As (V) and As (III) were determined by high performance liquid chromatography and inductively coupled plasma mass spectrometry after mineralization of samples by concentrated nitric acid. Toxicological analysis revealed high concentrations of arsenic in biological fluids as well as in organs. Histopathological examination showed a typical indication of myocarditis. These findings were in agreement with acute arsenic poisoning. The symptoms developed by this young woman (intoxication by intravenous administration) were comparable to oral intoxication. The clinical signs, survival time, and administration type are discussed in light of the literature on acute and chronic arsenic poisoning.