Is There a Relationship Between Bladder Outlet Obstruction due to Benign Prostatic Hyperplasia and Pulmonary Thromboembolism?
Article first published online: 23 JAN 2012
© 2012 American Academy of Forensic Sciences
Journal of Forensic Sciences
Volume 57, Issue 3, pages 663–664, May 2012
How to Cite
Rosenfeld, H. E. and Byard, R. W. (2012), Is There a Relationship Between Bladder Outlet Obstruction due to Benign Prostatic Hyperplasia and Pulmonary Thromboembolism?. Journal of Forensic Sciences, 57: 663–664. doi: 10.1111/j.1556-4029.2011.02042.x
- Issue published online: 19 APR 2012
- Article first published online: 23 JAN 2012
- Received 24 Feb. 2011; and in revised form 19 April 2011; accepted 23 April 2011.
- forensic science;
- pulmonary thromboembolism;
- deep venous thrombosis;
- benign prostatic hyperplasia;
- bladder outflow obstruction
Abstract: Benign prostatic hyperplasia with chronic bladder outlet obstruction has been associated with deep venous thrombosis (DVT) and fatal pulmonary thromboembolism (PTE). To evaluate this further, 60 autopsy cases of men with PTE were compared with 60 age-matched controls. The criteria for outlet obstruction were macroscopic prostatic enlargement with bladder trabeculation and benign prostatic hyperplasia on microscopy. Ten of the 60 men (16.7%) with fatal PTE had evidence of bladder outlet obstruction (age 57–78 years; mean 71.4 years). Of the 60 controls, 12 had evidence of bladder outlet obstruction (20%) (age 67–86 years; mean 75.5 years). No significant relationship could be demonstrated between bladder outlet obstruction and fatal PTE cases (p = 0.8). Given reports of this association, however, it is possible that bladder distension with venous compression may act as a risk modifier in certain individuals in association with other significant comorbidities, but this risk appears low.