Lower Extremity Deep Venous Thrombosis with Fatal Pulmonary Thromboembolism Caused by Benign Pelvic Space-Occupying Lesions—An Overview
Article first published online: 23 JAN 2012
© 2012 American Academy of Forensic Sciences
Journal of Forensic Sciences
Volume 57, Issue 3, pages 665–668, May 2012
How to Cite
Rosenfeld, H. and Byard, R. W. (2012), Lower Extremity Deep Venous Thrombosis with Fatal Pulmonary Thromboembolism Caused by Benign Pelvic Space-Occupying Lesions—An Overview. Journal of Forensic Sciences, 57: 665–668. doi: 10.1111/j.1556-4029.2011.02047.x
- Issue published online: 19 APR 2012
- Article first published online: 23 JAN 2012
- Received 7 Feb. 2011; and in revised form 19 April 2011; accepted 23 April 2011.
- deep venous thrombosis;
- forensic science;
- pelvic mass;
- pulmonary thromboembolism;
- venous stasis
Abstract: Venous stasis predisposes to thrombosis. One hundred and sixty cases of fatal pulmonary thromboembolism were reviewed to determine how many cases had deep venous thromboses associated with venous blood flow reduction caused by external pressure from benign pelvic masses. Three cases were identified, representing 2% of cases overall (3/160): a 44-year-old woman with a large uterine leiomyoma (1048 g); a 74-year-old man with prostatomegaly and bladder distension (containing 1 L of urine); and a 70-year-old man with prostatomegaly and bladder distension (containing 3 L of urine). Although a rare cause of fatal deep venous thrombosis and pulmonary thromboembolism, space-occupying pelvic lesions can lead to extrinsic pressure on adjacent veins reducing blood flow and causing stasis and thrombosis. Individuals with large pelvic masses may, therefore, be at increased risk of pulmonary thromboembolism from deep venous thrombosis, particularly in the presence of concurrent risk factors such as immobility, thrombophilias, malignancy, and significant cardiopulmonary disease.