Presented at the 88th Annual Meeting of the German Society of Legal Medicine (DGRM), September 22–26, 2009, in Basel, Switzerland, and at the 62nd Annual Meeting of the American Academy of Forensic Sciences, February 22–27, 2010, in Seattle, WA.
TECHNICAL NOTE PATHOLOGY/BIOLOGY
A Minimally Invasive Technique for the Detection and Analysis of Pulmonary Fat Embolism: A Feasibility Study*
Article first published online: 17 APR 2012
© 2012 American Academy of Forensic Sciences
Journal of Forensic Sciences
Volume 57, Issue 5, pages 1329–1335, September 2012
How to Cite
Filograna, L., Bolliger, S. A., Kneubuehl, B., Jackowski, C., Hatch, G. M. and Thali, M. J. (2012), A Minimally Invasive Technique for the Detection and Analysis of Pulmonary Fat Embolism: A Feasibility Study. Journal of Forensic Sciences, 57: 1329–1335. doi: 10.1111/j.1556-4029.2012.02134.x
- Issue published online: 5 SEP 2012
- Article first published online: 17 APR 2012
- Received 19 Jan. 2011; and in revised form 29 April 2011; accepted 8 July 2011.
- forensic science;
- forensic pathology;
- virtual autopsy;
- pulmonary fat embolism;
- percutaneous needle biopsy;
- double-edged knife
Abstract: We investigated the feasibility of postmortem percutaneous needle biopsy (PNB) for obtaining pulmonary samples adequate for the study of pulmonary fat embolism (PFE). Samples of both lungs were obtained from 26 cadavers via two different methods: (i) PNB and (ii) the double-edged knife technique, the gold standard at our institute. After water storage and Sudan III staining, six forensic pathologists independently examined all samples for the presence and severity of PFE. The results were compared and analyzed in each case regarding the vitality of the PFE and its relationship to the cause of death. The results showed that PFE was almost identically diagnosed and graded on the samples obtained via both methods. The discrepancies between the two techniques did not affect the diagnoses of vitality or cause of death related to PFE. This study demonstrates the feasibility of the PNB sampling method for the diagnosis and interpretation of PFE in the postmortem setting.