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LSD and 9,10-dihydro-LSD Analyses in Street Drug Blotter Samples via Easy Ambient Sonic-Spray Ionization MassSpectrometry (EASI-MS)

Authors

  • Wanderson Romão Ph.D.,

    Corresponding author
    1. ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, State University of Campinas – UNICAMP, Campinas, SP, Brazil
    2. Department of Chemistry, Federal University of Espírito Santo, Vitória, ES, Brazil
    • Additional information and reprint requests:

      Wanderson Romão, Ph.D.

      ThoMSon Mass Spectrometry Laboratory

      Institute of Chemistry

      State University of Campinas – UNICAMP

      Campinas, SP 13084-971

      Brazil

      E-mail: wandersonromao@gmail.com

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  • Bruno D. Sabino Ph.D.,

    1. Carlos Éboli Institute of Criminalistic, Rio de Janeiro, Brazil
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  • Maria Izabel M.S. Bueno Ph.D.,

    1. ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, State University of Campinas – UNICAMP, Campinas, SP, Brazil
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  • Boniek G. Vaz Ph.D.,

    1. ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, State University of Campinas – UNICAMP, Campinas, SP, Brazil
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  • Amadeu C. Júnior M.Sc.,

    1. Carlos Éboli Institute of Criminalistic, Rio de Janeiro, Brazil
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  • Adriano O. Maldaner Ph.D.,

    1. Brazilian Federal Police, Ministry of Justice, National Institute of Criminalistic – INC, Brasilia, DF, Brazil
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  • Eustáquio V.R. de Castro Ph.D.,

    1. Department of Chemistry, Federal University of Espírito Santo, Vitória, ES, Brazil
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  • Rogério A. Lordeiro M.Sc.,

    1. Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    2. Institute of Criminalistic – Civil Police of Minas Gerais, Belo Horizonte, MG, Brazil
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  • Clésia C. Nascentes Ph.D.,

    1. Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
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  • Marcos N. Eberlin Ph.D.,

    1. ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, State University of Campinas – UNICAMP, Campinas, SP, Brazil
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  • Rodinei Augusti Ph.D.

    1. Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
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  • Funded by the FAPESP (2009/07168-9), CNPq (576183/2008-3), FAPERJ (E-26/190.060/2008), FINEP, and FAPEMIG (PRONEX 479/2007).

Abstract

Normally, the identification of the LSD drug is performed by forensic laboratories, using the Ehrlich spot test. However, this is a nonspecific analysis. Additionally, the Brazilian Federal Police has identified the presence of a new compound in seized blotters: 9,10-dihydro-LSD, an uncontrolled substance. In this work, easy ambient sonic-spray ionization mass spectrometry in the positive ion mode, EASI(+)-MS, was used to characterize LSD and 9,10-dihydro-LSD compositions directly from the surface of blotters. The presence of LSD in the seized blotter samples were also confirmed via high-performance liquid chromatography with ultraviolet detector. In a set of 41 blotters analyzed by EASI(+)-MS, 28 showed positive results for LSD, seven for 9,10-dihydro-LSD, and another six samples showed negative results for both LSD and 9,10-dihydro-LSD. The combination of thin layer chromatography with EASI-MS also demonstrated to be a relatively simple and powerful screening tool for forensic analysis of street drugs.

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