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Table S1: CFTR Coding Sequence Accession Numbers

Table S2: Alternative Models of Molecular Evolution Applied to a CFTR Coding Sequence Alignment of 13 Mammalian Apecies and the Outgroup Taxon Platypus.

Table S3: Alternative Models of Molecular Evolution Applied to a Concatenated Mitochondrial Protein Coding Sequence Alignment of 13 Mammalian Apecies and the Outgroup Taxon Platypus.

Figure S1: Majority rule consensus (50%) Bayesian phylogenetic tree for the (A) CFTR and (B) the mitochondrial sequence alignments. A. The posterior probability distribution of CFTR trees was generated using a general time reversible model with a gamma distribution of rates and using maximum likelihood estimates of base frequencies. Values at nodes are the posterior probabilities of the specified clade, determined from 3750 trees sampled from the posterior distribution. The clade (Pig, (Cow, Sheep), (Cat, Dog)) has a posterior probability of 0.97, and the clade (Horse, (Pig, (Cow, Sheep), (Cat, Dog))) is represented in all sampled phylogenies (posterior probability = 1.0). The lineages leading to Horse, (Cat, Dog), and (Pig (Sheep, Cow)) are resolved as a polytomy on this tree. B. The posterior probability distribution of mitochondrial trees was generated under a general time reversible model with a gamma distribution of rates, a fixed proportion of invariant sites, and using maximum likelihood estimates of base frequencies. Support at all nodes is high, with posterior probabilities of 1.0 for all clades.

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FilenameFormatSizeDescription
EVO_278_sm_TableS1-S3-FigS1.doc278KSupporting info item
EVO_tables1-s3-figs1.doc278KSupporting info item

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