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Appendix S1. Sensitivity Analysis: Migration Rate's Effect on Fitness Value Estimates.

Figure S1. The effect of migration rate on estimates of fitness values for 15 gene arrangement karyotypes in six different niches using the 1940 inversion frequencies (Dobzhansky 1944).

Figure S2. The gene arrangement frequencies reached in six niches after 5000 generations in migration-selection recursions.

Figure S3. Selection with no migration.

Figure S4. No selection with migration.

Figure S5.Drosophila pseudoobscura gene arrangement frequency changes in six niches over 500 generations using fitness values estimated from the 1940 inversion frequency data (Dobzhansky 1944).

Figure S6.Drosophila pseudoobscura gene arrangement frequency changes in six niches over 500 generations using fitness values estimated from the 1940 inversion frequency data (Dobzhansky 1944).

Figure S7.Drosophila pseudoobscura gene arrangement frequency changes in six niches over 500 generations using fitness values estimated from the 1960 inversion frequency data (Dobzhansky 1944).

Figure S8.Drosophila pseudoobscura gene arrangement frequency changes in six niches over 500 generations using fitness values estimated from the 1980 inversion frequency data (Dobzhansky 1944).

Figure S9.Drosophila pseudoobscura gene arrangement frequency changes in six niches over 600 generations using fitness values estimated from the 1940, 1960, and 1980 inversion frequency data (Anderson et al. 1991; Dobzhansky 1944).

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