RECOMBINATION AND HITCHHIKING OF DELETERIOUS ALLELES
Article first published online: 26 APR 2011
© 2011 The Author(s)
Volume 65, Issue 9, pages 2421–2434, September 2011
How to Cite
Hartfield, M. and Otto, S. P. (2011), RECOMBINATION AND HITCHHIKING OF DELETERIOUS ALLELES. Evolution, 65: 2421–2434. doi: 10.1111/j.1558-5646.2011.01311.x
- Issue published online: 1 SEP 2011
- Article first published online: 26 APR 2011
- Accepted manuscript online: 6 APR 2011 07:59AM EST
- Received December 17, 2010, Accepted March 18, 2011
Appendix S1. Testing the effect of recombination on the fixation of a linked, neutral allele.
Appendix S2. Methods used for multilocus simulations.
Appendix S3. Derivations in mathematica (HartfieldOttoSM.nb file available for download).
Figure S1. The mean frequency of a linked neutral allele following a successful selective sweep, given as a function of the recombination rate Nr between different sites.
Figure S2. The mean number of deleterious alleles that fix genome-wide following the completion of a successful selection sweep, given as a function of the recombination rate NR (see Fig. 4 for data presented relative to Sa = 0). Sa = 0 (black dashed line), 20 (black solid line), 40 (dark gray), or 80 (light gray).
Figure S3. Fixation probability of the advantageous mutant in multilocus simulations, as a function of the recombination rate NR. Sa = 0 (black dashed line), 20 (black solid line), 40 (dark gray), or 80 (light gray).
Figure S4. Fixation probability of a recombinant carrying two beneficial mutations.
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