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Table S1. Estimates of life-history traits and references.

Table S2. The number of bases analyzed for each chromosome.

Table S3. Ninety-five percent confidence intervals for substitution rates.

Table S4. Ninety-five percent confidence intervals for the male-to-female mutation rate ratio (α).

Table S5. Correcting branch-specific α estimates for ancestral polymorphism.

Table S6. Multiple regression models with at least one significant predictor.

Table S7. Substitution rates on the autosomes, chromosome X, the X-to-autosome ratio, and α computed for the species with high coverage genomes (6X or greater) either including or excluding ultra-conserved elements (UCEs).

Table S8. Comparison of regression results from the full model (including all available mammalian genome sequences) with models reduced to genomes sequenced to greater than 6× coverage, either including or excluding ultra-conserved elements (UCEs).

Table S9. Regression results correlating life-history traits with α, where α is computed using a variety of X partitions.

Table S10. Correcting pairwise α estimates for ancestral polymorphism.

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