GENETIC VARIATION AND DNA REPLICATION TIMING, OR WHY IS THERE LATE REPLICATING DNA?
Article first published online: 5 AUG 2011
© 2011 The Author(s). Evolution© 2011 The Society for the Study of Evolution.
Volume 65, Issue 11, pages 3031–3047, November 2011
How to Cite
Herrick, J. (2011), GENETIC VARIATION AND DNA REPLICATION TIMING, OR WHY IS THERE LATE REPLICATING DNA?. Evolution, 65: 3031–3047. doi: 10.1111/j.1558-5646.2011.01407.x
- Issue published online: 24 OCT 2011
- Article first published online: 5 AUG 2011
- Accepted manuscript online: 13 JUL 2011 07:27PM EST
- Received February 23, 2011, Accepted June 29, 2011
- mutation rate;
- ribonucleotide reductase;
- transposable elements
Mutation rates vary significantly within the genome and across species. Recent studies revealed a long suspected replication-timing effect on mutation rate, but the mechanisms that regulate the increase in mutation rate as the genome is replicated remain unclear. Evidence is emerging, however, that DNA repair systems, in general, are less efficient in late replicating heterochromatic regions compared to early replicating euchromatic regions of the genome. At the same time, mutation rates in both vertebrates and invertebrates have been shown to vary with generation time (GT). GT is correlated with genome size, which suggests a possible nucleotypic effect on species-specific mutation rates. These and other observations all converge on a role for DNA replication checkpoints in modulating generation times and mutation rates during the DNA synthetic phase (S phase) of the cell cycle. The following will examine the potential role of the intra-S checkpoint in regulating cell cycle times (GT) and mutation rates in eukaryotes. This article was published online on August 5, 2011. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected October 4, 2011.